14530903

Source:http://linkedlifedata.com/resource/pubmed/id/14530903

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0009647, umls-concept:C0021467, umls-concept:C0021469, umls-concept:C0205275, umls-concept:C0243076, umls-concept:C0289174, umls-concept:C1442162, umls-concept:C1550718, umls-concept:C1627358, umls-concept:C2349975
pubmed:issue	3-4
pubmed:dateCreated	2003-10-7
pubmed:abstractText	Clozapine-like atypical antipsychotic drugs, such as olanzapine, risperidone and sertindole, bind most strongly to 5-HT(2A) receptors, which may contribute to their antipsychotic effects. Antipsychotic drugs, such as clozapine and haloperidol, have been found to enhance latent inhibition (LI) in humans and rats. LI is a process of learning to ignore irrelevant stimuli that is disrupted in acute, positive-symptom schizophrenia, and can be modelled in animals.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7608025
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/2-((2-(dimethylamino)ethyl)thio)-3-p..., http://linkedlifedata.com/resource/pubmed/chemical/5-Hydroxytryptophan, http://linkedlifedata.com/resource/pubmed/chemical/8-Hydroxy-2-(di-n-propylamino)tetral..., http://linkedlifedata.com/resource/pubmed/chemical/Amphetamine, http://linkedlifedata.com/resource/pubmed/chemical/Central Nervous System Stimulants, http://linkedlifedata.com/resource/pubmed/chemical/Fluorobenzenes, http://linkedlifedata.com/resource/pubmed/chemical/Phencyclidine, http://linkedlifedata.com/resource/pubmed/chemical/Phenols, http://linkedlifedata.com/resource/pubmed/chemical/Quinolines, http://linkedlifedata.com/resource/pubmed/chemical/SR 46349B, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin 5-HT2 Receptor Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0033-3158
pubmed:author	pubmed-author:GrayJ AJA, pubmed-author:JosephM HMH, pubmed-author:McDonaldL MLM, pubmed-author:MolosM AMA, pubmed-author:StephensonJ DJD, pubmed-author:VythelingumG NGN
pubmed:issnType	Print
pubmed:volume	169
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	321-31
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:14530903-5-Hydroxytryptophan, pubmed-meshheading:14530903-8-Hydroxy-2-(di-n-propylamino)tetralin, pubmed-meshheading:14530903-Aging, pubmed-meshheading:14530903-Amphetamine, pubmed-meshheading:14530903-Analysis of Variance, pubmed-meshheading:14530903-Animals, pubmed-meshheading:14530903-Association Learning, pubmed-meshheading:14530903-Behavior, Animal, pubmed-meshheading:14530903-Central Nervous System Stimulants, pubmed-meshheading:14530903-Conditioning, Classical, pubmed-meshheading:14530903-Dose-Response Relationship, Drug, pubmed-meshheading:14530903-Drug Interactions, pubmed-meshheading:14530903-Fluorobenzenes, pubmed-meshheading:14530903-Inhibition (Psychology), pubmed-meshheading:14530903-Male, pubmed-meshheading:14530903-Phencyclidine, pubmed-meshheading:14530903-Phenols, pubmed-meshheading:14530903-Quinolines, pubmed-meshheading:14530903-Rats, pubmed-meshheading:14530903-Rats, Sprague-Dawley, pubmed-meshheading:14530903-Serotonin 5-HT2 Receptor Antagonists, pubmed-meshheading:14530903-Serotonin Receptor Agonists, pubmed-meshheading:14530903-Stereotyped Behavior
pubmed:year	2003
pubmed:articleTitle	Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and conditioning.
pubmed:affiliation	Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. Louise_McDonald@Merck.com
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't