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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2003-10-7
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pubmed:abstractText |
Adaptive cytoprotection is the process by which the pretreatment of cells with low concentrations of a noxious agent prevents the damage caused by a subsequent exposure of those cells to higher concentrations of that same agent. In this study, a human gastric carcinoma cell line was used to examine the molecular mechanism of adaptive cytoprotection induced by ethanol. Pretreatment of cells with 1%-4% ethanol made cells resistant to a subsequent exposure to 8% ethanol. This adaptive cytoprotection was accompanied by an increase in prostaglandin E2 synthesis and was partially inhibited by inhibitors of cyclooxygenase-2, but not by an inhibitor of cyclooxygenase-1. Furthermore, the adaptive cytoprotection was not dependent on newly synthesized proteins and was inhibited by a protein tyrosine kinase inhibitor. Based on these results, it is proposed that the stimulation of cyclooxygenase-2-dependent prostaglandin E2 synthesis, which is regulated post-translationally by protein tyrosine phosphorylation, plays an important role in adaptive cytoprotection induced by ethanol in gastric cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanol,
http://linkedlifedata.com/resource/pubmed/chemical/Genistein,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1535-3702
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
228
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1089-95
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14530521-Cell Line, Tumor,
pubmed-meshheading:14530521-Culture Media,
pubmed-meshheading:14530521-Cyclooxygenase 1,
pubmed-meshheading:14530521-Cyclooxygenase 2,
pubmed-meshheading:14530521-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:14530521-Cyclooxygenase Inhibitors,
pubmed-meshheading:14530521-Cytoprotection,
pubmed-meshheading:14530521-Dinoprostone,
pubmed-meshheading:14530521-Dose-Response Relationship, Drug,
pubmed-meshheading:14530521-Enzyme Inhibitors,
pubmed-meshheading:14530521-Ethanol,
pubmed-meshheading:14530521-Genistein,
pubmed-meshheading:14530521-Humans,
pubmed-meshheading:14530521-Indomethacin,
pubmed-meshheading:14530521-Isoenzymes,
pubmed-meshheading:14530521-Membrane Proteins,
pubmed-meshheading:14530521-Phosphorylation,
pubmed-meshheading:14530521-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:14530521-Prostaglandins,
pubmed-meshheading:14530521-Protein Processing, Post-Translational,
pubmed-meshheading:14530521-Stomach,
pubmed-meshheading:14530521-Time Factors,
pubmed-meshheading:14530521-Tyrosine
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pubmed:year |
2003
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pubmed:articleTitle |
Molecular mechanism of adaptive cytoprotection induced by ethanol in human gastric cells.
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pubmed:affiliation |
Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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