14528517

Source:http://linkedlifedata.com/resource/pubmed/id/14528517

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003865, umls-concept:C0025677, umls-concept:C0034693, umls-concept:C0034721, umls-concept:C0079189, umls-concept:C0333348, umls-concept:C0441889, umls-concept:C0443199, umls-concept:C0729218, umls-concept:C1280500
pubmed:issue	10
pubmed:dateCreated	2003-10-6
pubmed:abstractText	To investigate the effects of prophylactic and therapeutic treatments with FK506 (tacrolimus), an immunosuppressive drug that specifically inhibits T cell activation, and methotrexate (MTX) on inflammatory cytokines, tumor necrosis factor (TNF)-a, interleukin (IL)-1beta, and IL-6 levels in rat adjuvant-induced arthritis (AIA).
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7501984
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6, http://linkedlifedata.com/resource/pubmed/chemical/Methotrexate, http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0315-162X
pubmed:author	pubmed-author:GotoToshioT, pubmed-author:MagariKatsueK, pubmed-author:MiyataSusumuS, pubmed-author:MutohSeitaroS, pubmed-author:NishigakiFusakoF, pubmed-author:OhkuboYoshitakaY
pubmed:issnType	Print
pubmed:volume	30
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2193-200
pubmed:dateRevised	2004-11-17
pubmed:meshHeading	pubmed-meshheading:14528517-Animals, pubmed-meshheading:14528517-Arthritis, Experimental, pubmed-meshheading:14528517-Cytokines, pubmed-meshheading:14528517-Disease Models, Animal, pubmed-meshheading:14528517-Dose-Response Relationship, Drug, pubmed-meshheading:14528517-Drug Administration Schedule, pubmed-meshheading:14528517-Edema, pubmed-meshheading:14528517-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:14528517-Female, pubmed-meshheading:14528517-Hindlimb, pubmed-meshheading:14528517-Immunosuppressive Agents, pubmed-meshheading:14528517-Interleukin-1, pubmed-meshheading:14528517-Interleukin-6, pubmed-meshheading:14528517-Methotrexate, pubmed-meshheading:14528517-Rats, pubmed-meshheading:14528517-Rats, Inbred Lew, pubmed-meshheading:14528517-Tacrolimus, pubmed-meshheading:14528517-Tumor Necrosis Factor-alpha
pubmed:year	2003
pubmed:articleTitle	Differential effects of FK506 and methotrexate on inflammatory cytokine levels in rat adjuvant-induced arthritis.
pubmed:affiliation	Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., 2-1-6 Kashima, Yodogawa-ku, Osaka 532-8514, Japan.
pubmed:publicationType	Journal Article