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pubmed:abstractText |
Eleven imidazole diselenides derived from the naturally occurring family of antioxidants, the ovothiols, were synthetised by cyclisation of selenoamides with trimethylsilyltrifluoromethanesulfonate or refluxing of cyanoamines in a selenium/sodium borohydride mixture. These compounds were assayed for their glutathione peroxidase-like (GSH Px-like) activity and their capacity to be reduced by glutathione. The most active molecules of the series were 4 times more potent in the GSH Px-like test than the widely known reference compound, ebselen. This catalytic activity was mediated by the formation of the antioxidant selenol intermediate upon partial but significant exchange reaction with glutathione.
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pubmed:affiliation |
Laboratoire de Chimie Organique Macromoléculaire, CNRS UMR 8009, USTL, Bâtiment C3, UST Lille I, 59655 Villeneuve d'Ascq, France. fabrice.bailly@univ-lille1.fr
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