Source:http://linkedlifedata.com/resource/pubmed/id/14526407
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
|
pubmed:dateCreated |
2003-10-3
|
pubmed:abstractText |
Transplantation of organs procured from donors with malignancies identified subsequent to implantation presents a significant dilemma regarding the optimal management strategy to simultaneously minimize the risk for cancer transmission and recipient morbidity. In this report, we present a patient who underwent orthotopic liver transplantation for hepatitis B cirrhosis. The donor had no previous history of cancer. On autopsy, enlarged mediastinal lymph nodes led to the discovery of a 1-cm lung tumor. Histological examination showed pulmonary adenocarcinoma with metastatic mediastinal disease. Despite urgent retransplantation within 7 days, the recipient developed metastatic pulmonary adenocarcinoma diagnosed 11 months after transplantation and died soon thereafter. Analysis of short tandem repeat regions of chromosomal DNA from the recipient, the 2 liver donors, and the posttransplantation tumor corroborates that the first donor was the source of the malignancy. This case of donor-transmitted malignancy underscores the need for vigilance by the procuring surgeon in identifying potential malignancy during organ retrieval and use of a full autopsy on selected donors after organ procurement.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
1527-6465
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
9
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1102-7
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:14526407-Adenocarcinoma,
pubmed-meshheading:14526407-Adult,
pubmed-meshheading:14526407-Fatal Outcome,
pubmed-meshheading:14526407-Hepatitis B, Chronic,
pubmed-meshheading:14526407-Humans,
pubmed-meshheading:14526407-Liver Transplantation,
pubmed-meshheading:14526407-Lung Neoplasms,
pubmed-meshheading:14526407-Male,
pubmed-meshheading:14526407-Middle Aged,
pubmed-meshheading:14526407-Reoperation,
pubmed-meshheading:14526407-Tissue Donors
|
pubmed:year |
2003
|
pubmed:articleTitle |
Death from donor-transmitted malignancy despite emergency liver retransplantation.
|
pubmed:affiliation |
Division of Transplantation, Department of Surgery, University of California, San Francisco, CA 94143, USA.
|
pubmed:publicationType |
Journal Article,
Case Reports
|