| pubmed-article:14525773 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14525773 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:14525773 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14525773 | lifeskim:mentions | umls-concept:C0005953 | lld:lifeskim |
| pubmed-article:14525773 | lifeskim:mentions | umls-concept:C1449575 | lld:lifeskim |
| pubmed-article:14525773 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:14525773 | lifeskim:mentions | umls-concept:C1522053 | lld:lifeskim |
| pubmed-article:14525773 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:14525773 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14525773 | pubmed:dateCreated | 2004-1-19 | lld:pubmed |
| pubmed-article:14525773 | pubmed:abstractText | Interleukin-5 (IL-5) is a hematopoietic differentiation factor that promotes the development of mature eosinophils from progenitors in bone marrow. We present a multifactorial microarray study documenting the transcriptional events in bone marrow of wild-type and IL-5-deficient mice at baseline and in response to infection with Schistosoma mansoni. The microarray data were analyzed by a 4-way subtractive algorithm that eliminated confounding non-IL-5-related sequelae of schistosome infection as well as alterations in gene expression among uninfected mice. Among the most prominent findings, we observed 7- to 40-fold increased expression of transcripts encoding the classic eosinophil granule proteins (eosinophil peroxidase, major basic protein, the ribonucleases) together with arachidonate-15-lipoxygenase and protease inhibitor plasminogen activator inhibitor 2 (PAI-2), in the IL-5-producing, infected wild-type mice only. This was accompanied by increased transcription of genes involved in secretory protein biosynthesis and granule-vesicle formation. Interestingly, we did not detect increased expression of genes encoding eosinophil-related chemokine receptors (CCR1, CCR3) or members of the GATA or CCAAT/enhancer binding protein (C/EBP) transcription factor families. These data suggest that the IL-5-responsive progenitors in the mouse bone marrow are already significantly committed to the eosinophil lineage and that IL-5 promotes differentiation of these committed progenitors into cells with recognizable and characteristic cytoplasmic granules and granule proteins. | lld:pubmed |
| pubmed-article:14525773 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14525773 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14525773 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:14525773 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14525773 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14525773 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14525773 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14525773 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14525773 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:14525773 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:14525773 | pubmed:author | pubmed-author:WynnThomas... | lld:pubmed |
| pubmed-article:14525773 | pubmed:author | pubmed-author:RosenbergHele... | lld:pubmed |
| pubmed-article:14525773 | pubmed:author | pubmed-author:DomachowskeJo... | lld:pubmed |
| pubmed-article:14525773 | pubmed:author | pubmed-author:ByströmJonasJ | lld:pubmed |
| pubmed-article:14525773 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14525773 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:14525773 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:14525773 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14525773 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14525773 | pubmed:pagination | 868-77 | lld:pubmed |
| pubmed-article:14525773 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:14525773 | pubmed:meshHeading | pubmed-meshheading:14525773... | lld:pubmed |
| pubmed-article:14525773 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14525773 | pubmed:articleTitle | Gene microarray analysis reveals interleukin-5-dependent transcriptional targets in mouse bone marrow. | lld:pubmed |
| pubmed-article:14525773 | pubmed:affiliation | NIAID, NIH, Bldg 10, Rm 11N104, 9000 Rockville Pike, Bethesda, MD, 20892, USA. jbystrom@niaid.nih.gov | lld:pubmed |
| pubmed-article:14525773 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14525773 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14525773 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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