Linked Life Data

14525524

Source:http://linkedlifedata.com/resource/pubmed/id/14525524

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-10-3
pubmed:abstractText
Ovaries can be considered tissues in which endocrine organs--follicles and corpora lutea--continually grow and regress. Follicles have both epithelial and stromal layers in which cell migration or movement, cell division, specialization and differentiation, and death occur. A fluid-filled antrum develops and at ovulation the epithelial cells undergo an epithelial to mesenchymal transition into luteal cells. Although growth factors and hormones are very important in some of these processes, the extracellular matrix participates in all of them. Importantly, the matrix is diverse in composition and cells rarely behave without reference to the composition and structure of the matrix. When follicles commence growing, the follicular basal lamina changes in its composition from containing all six alpha chains of collagen type IV to only alpha 1 and alpha 2. Perlecan and nidogen 1 subsequently become components of the follicular basal lamina, and there is an increase in the amount of laminin chains alpha 1, beta 2 and gamma 1, at least in cows. Late in follicular development and on atresia some follicles contain laminin alpha 2. On atresia the follicular basal lamina is not degraded as occurs at ovulation, but can be breached by cells from the thecal layer if granulosa cells no longer align it. Other matrix components are present and also change during follicular development. Versican was identified in all the follicular layers and has been found to play a key role together with inter-alpha-trypsin inhibitor, tumour necrosis factor alpha-stimulated gene 6 (TSG-6) and hyaluronan in cumulus oocyte expansion and fertility. Recent studies are directed at investigating the regulation of the matrix and its function in the ovary.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1470-1626
pubmed:author
pubmed:issnType
Print
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
415-24
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Extracellular matrix of the developing ovarian follicle.
pubmed:affiliation
Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, University of Adelaide, South Australia 5005, Australia. ray.rodgers@adelaide.edu.au
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't