Linked Life Data

14523964

Source:http://linkedlifedata.com/resource/pubmed/id/14523964

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-10-2
pubmed:abstractText
Dynamic ventilation imaging using laser-polarized (3)He has a promising potential for elucidating the physiology and physiopathology of the lungs. In this study, a methodological approach is proposed for the assessment and quantification of local ventilation parameters. High-temporal-resolution coronal ventilation image series were obtained with a projection-reconstruction (PR) sequence combined with the sliding-window technique. After image series were processed, parametric pixel-by-pixel maps of the gas arrival time, filling time constant, inflation rate, and gas volume were generated. The acquisition technique and the signal processing procedure, which are referred to collectively as sliding pulmonary imaging for respiratory overview (SPIRO), were tested in vivo in healthy rat lungs using a contrast media injector for controlled (3)He flow and volume injection in the animal lungs. The same protocol was applied to broncho-constriction animal models using intravenous injection of methacholine solution. Inflation rate values measured in the lungs were found to decrease with increasing doses of injected methacholine solution. This study demonstrates that it is possible to obtain quantitative regional gas dynamic information using the SPIRO technique in a single polarized gas inspiration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0740-3194
pubmed:author
pubmed:copyrightInfo
Copyright 2003 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
777-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Dynamic 3He imaging for quantification of regional lung ventilation parameters.
pubmed:affiliation
Laboratoire de RMN, CNRS 5012, Université Lyon-1, Villeurbanne, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't