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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2003-10-2
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pubmed:abstractText |
Expression profiling has demonstrated that transcriptomes of primary malignancies differ from those in normal tissue. It is unknown, however, whether there exist "surrogate" transcriptional markers in peripheral blood mononuclear cells (PBMCs) of patients with solid tumors. We identified transcripts expressed differentially between PBMCs from renal cell carcinoma patients and normal subjects, some of which appear to reflect specific immune responses of circulating cells. We also identified small sets of predictor genes distinguishing PBMCs from renal cell carcinoma patients and normal volunteers with high accuracy. The present findings have important implications for diagnosis and future clinical pharmacogenomic studies of antitumor therapies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0008-5472
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pubmed:author |
pubmed-author:BurczynskiMichael EME,
pubmed-author:DornerAndrew JAJ,
pubmed-author:DukartGaryG,
pubmed-author:DutcherJaniceJ,
pubmed-author:HidalgoManuelM,
pubmed-author:HudesGaryG,
pubmed-author:LoganTheodoreT,
pubmed-author:MarshallBonnieB,
pubmed-author:SlonimDonna KDK,
pubmed-author:StadlerWalterW,
pubmed-author:StoverJennifer AJA,
pubmed-author:TrepicchioWilliam LWL,
pubmed-author:TwineNatalie CNC
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6069-75
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:14522937-Adult,
pubmed-meshheading:14522937-Aged,
pubmed-meshheading:14522937-Carcinoma, Renal Cell,
pubmed-meshheading:14522937-Female,
pubmed-meshheading:14522937-Gene Expression Profiling,
pubmed-meshheading:14522937-Humans,
pubmed-meshheading:14522937-Kidney Failure, Chronic,
pubmed-meshheading:14522937-Kidney Neoplasms,
pubmed-meshheading:14522937-Leukocytes, Mononuclear,
pubmed-meshheading:14522937-Male,
pubmed-meshheading:14522937-Middle Aged,
pubmed-meshheading:14522937-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:14522937-RNA, Messenger,
pubmed-meshheading:14522937-Transcription, Genetic
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pubmed:year |
2003
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pubmed:articleTitle |
Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma.
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pubmed:affiliation |
Discovery Medicine, Wyeth Research, Cambridge, Massachusetts 02140, USA.
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pubmed:publicationType |
Journal Article
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