| pubmed-article:14522872 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14522872 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:14522872 | lifeskim:mentions | umls-concept:C1420326 | lld:lifeskim |
| pubmed-article:14522872 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:14522872 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:14522872 | lifeskim:mentions | umls-concept:C1550500 | lld:lifeskim |
| pubmed-article:14522872 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:14522872 | pubmed:dateCreated | 2003-10-23 | lld:pubmed |
| pubmed-article:14522872 | pubmed:abstractText | In Xenopus laevis, beta-catenin-mediated dorsal axis formation can be suppressed by overexpression of the HMG-box transcription factor XSOX3. Mutational analysis indicates that this effect is due not to the binding of XSOX3 to beta-catenin nor to its competition with beta-catenin-regulated TCF-type transcription factors for specific DNA binding sites, but rather to SOX3 binding to sites within the promoter of the early VegT- and beta-catenin-regulated dorsal-mesoderm-inducing gene Xnr5. Although B1-type SOX proteins, such as XSOX3, are commonly thought to act as transcriptional activators, XSOX3 acts as a transcriptional repressor of Xnr5 in both the intact embryo and animal caps injected with VegT RNA. Expression of a chimeric polypeptide composed of XSOX3 and a VP16 transcriptional activation domain or morpholino-induced decrease in endogenous XSOX3 polypeptide levels lead to an increase in Xnr5 expression, as does injection of an anti-XSOX3 antibody that inhibits XSOX3 DNA binding. These observations indicate that maternal XSOX3 acts in a novel manner to restrict Xnr5 expression to the vegetal hemisphere. | lld:pubmed |
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| pubmed-article:14522872 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14522872 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14522872 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14522872 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14522872 | pubmed:issn | 0950-1991 | lld:pubmed |
| pubmed-article:14522872 | pubmed:author | pubmed-author:KlymkowskyM... | lld:pubmed |
| pubmed-article:14522872 | pubmed:author | pubmed-author:ZhangChiC | lld:pubmed |
| pubmed-article:14522872 | pubmed:author | pubmed-author:BastaTamaraT | lld:pubmed |
| pubmed-article:14522872 | pubmed:author | pubmed-author:JensenEric... | lld:pubmed |
| pubmed-article:14522872 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14522872 | pubmed:volume | 130 | lld:pubmed |
| pubmed-article:14522872 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14522872 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14522872 | pubmed:pagination | 5609-24 | lld:pubmed |
| pubmed-article:14522872 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:14522872 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14522872 | pubmed:articleTitle | The beta-catenin/VegT-regulated early zygotic gene Xnr5 is a direct target of SOX3 regulation. | lld:pubmed |
| pubmed-article:14522872 | pubmed:affiliation | Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA. | lld:pubmed |
| pubmed-article:14522872 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14522872 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14522872 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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