Linked Life Data

14521544

Source:http://linkedlifedata.com/resource/pubmed/id/14521544

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-10-2
pubmed:abstractText
Ectopic budding of the initial ureter from the Wolffian duct is the first ontogenic misstep that leads to many congenital anomalies of the kidney and urinary tract (CAKUT). The ectopia results in hypoplastic kidney, ectopia of ureterovesical orifice, urinary outflow obstruction and/or reflux. Recent studies on several mutant mouse models verified that ectopic ureteric budding indeed occurs prior to the formation of CAKUT. Often, the genes involved in navigating the site of ureteric budding also regulate later ontogenic processes of the kidney and other urinary tract systems. These additional functions of the genes underlie the wide spectrum of CAKUT, for example multicystic dysplastic kidney, megaureter and atretic ureter, because the genes regulate the morphogenesis of the many portions of the excretory system through their distinctive cellular functions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1328-8067
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
598-604
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Ontogeny of congenital anomalies of the kidney and urinary tract, CAKUT.
pubmed:affiliation
Departments of Pediatrics and Medicine, Vanderbilt University Medical Center Nashville, TN, USA.
pubmed:publicationType
Journal Article