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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1993-1-6
|
| pubmed:abstractText |
To examine determinants of basal metabolic rate we studied 66 Type 2 (non-insulin-dependent) diabetic and 24 healthy age- and weight-matched control subjects with indirect calorimetry and infusion of [3H-3-] glucose. Eight Type 2 diabetic patients were re-studied after a period of insulin therapy. Basal metabolic rate was higher in Type 2 diabetic patients than in control subjects (102.8 +/- 1.9 J.kg LBM-1.min-1 vs 90.7 +/- 2.8 J.kg LBM-1.min-1; p less than 0.01) and decreased significantly with insulin therapy (p less than 0.01). The basal rate of hepatic glucose production was higher in Type 2 diabetic patients than in control subjects (1044.0 +/- 29.9 vs 789.3 +/- 41.7 mumol/min; p less than 0.001) and decreased after insulin therapy (p less than 0.01). Hepatic glucose production correlated positively with basal metabolic rate both in Type 2 diabetic patients (r = 0.49; p less than 0.001) and in control subjects (r = 0.50; p less than 0.05). Lipid oxidation was increased in Type 2 diabetic patients compared with control subjects (1.68 +/- 0.05 vs 1.37 +/- 0.08 mumol.kg LBM-1.min-1; p less than 0.01) and decreased significantly after insulin therapy (p less than 0.05). The rate of lipid oxidation correlated positively with basal metabolic rate both in Type 2 diabetic patients (r = 0.36; p less than 0.01) and in control subjects (r = 0.51; p less than 0.01). These data demonstrate that basal metabolic rate, rates of hepatic glucose production and lipid oxidation are interrelated in Type 2 diabetic patients.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0012-186X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
962-6
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1451954-Adolescent,
pubmed-meshheading:1451954-Adult,
pubmed-meshheading:1451954-Basal Metabolism,
pubmed-meshheading:1451954-Calorimetry,
pubmed-meshheading:1451954-Child,
pubmed-meshheading:1451954-Child, Preschool,
pubmed-meshheading:1451954-Diabetes Mellitus, Type 2,
pubmed-meshheading:1451954-Female,
pubmed-meshheading:1451954-Glucose,
pubmed-meshheading:1451954-Humans,
pubmed-meshheading:1451954-Infant,
pubmed-meshheading:1451954-Infant, Newborn,
pubmed-meshheading:1451954-Injections, Intravenous,
pubmed-meshheading:1451954-Insulin,
pubmed-meshheading:1451954-Lipid Metabolism,
pubmed-meshheading:1451954-Liver,
pubmed-meshheading:1451954-Male,
pubmed-meshheading:1451954-Oxidation-Reduction,
pubmed-meshheading:1451954-Tritium
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Factors associated with basal metabolic rate in patients with type 2 (non-insulin-dependent) diabetes mellitus.
|
| pubmed:affiliation |
Helsinki University Hospital, Fourth Department of Medicine, Finland.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|