Linked Life Data

14519492

Source:http://linkedlifedata.com/resource/pubmed/id/14519492

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-10-1
pubmed:abstractText
Although the fetal inflammatory response syndrome seems crucial to the association between intrauterine infection and white matter disease in human preterm infants, the underlying mechanisms remain unclear. Using our previously described rabbit model of cerebral cell death in the white matter and hippocampus induced by intrauterine Escherichia coli infection, we investigated inflammatory and astroglial responses in placenta and brain tissues, in correlation with cell death distribution. Brains and placentas were studied 12, 24, or 48 h following intrauterine inoculation of E. coli or saline (groups G12, G24, and G48). Diffuse monocyte-macrophage infiltrates positive for inducible nitric oxide synthase (i-NOS) were significantly more marked in G24 and G48 placentas than in controls. In the G48 fetuses with both diffuse cell death and focal periventricular white matter cysts mimicking cystic periventricular leukomalacia, a strong rabbit macrophage and inducible nitric oxide synthase immunostaining was observed at the border of these cystic lesions. In contrast, in the fetuses with only diffuse and significant cell death, no inflammatory or astroglial responses were detected in the white matter or hippocampus. Cell death was accompanied by i-NOS immunostaining in the hippocampus but not the white matter. Hippocampal cells positive for i-NOS usually displayed a neuronal phenotype. In this model, focal white matter cysts are accompanied by a robust inflammatory response, and diffuse cell death, which may mimic the white matter and hippocampal damage seen in very and extremely pre-term infants, occur in the absence of a detectable brain inflammatory response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
145
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-48
pubmed:dateRevised
2011-10-27
pubmed:meshHeading
pubmed-meshheading:14519492-Animals, pubmed-meshheading:14519492-Animals, Newborn, pubmed-meshheading:14519492-Cell Death, pubmed-meshheading:14519492-Cerebellum, pubmed-meshheading:14519492-Disease Models, Animal, pubmed-meshheading:14519492-Encephalitis, pubmed-meshheading:14519492-Escherichia coli Infections, pubmed-meshheading:14519492-Female, pubmed-meshheading:14519492-Glial Fibrillary Acidic Protein, pubmed-meshheading:14519492-Hippocampus, pubmed-meshheading:14519492-Humans, pubmed-meshheading:14519492-Immunochemistry, pubmed-meshheading:14519492-In Situ Nick-End Labeling, pubmed-meshheading:14519492-Inflammation, pubmed-meshheading:14519492-Leukocyte L1 Antigen Complex, pubmed-meshheading:14519492-Macrophages, pubmed-meshheading:14519492-Male, pubmed-meshheading:14519492-Nitric Oxide Synthase, pubmed-meshheading:14519492-Nitric Oxide Synthase Type II, pubmed-meshheading:14519492-Placenta Diseases, pubmed-meshheading:14519492-Pregnancy, pubmed-meshheading:14519492-Prenatal Exposure Delayed Effects, pubmed-meshheading:14519492-Rabbits, pubmed-meshheading:14519492-Time Factors
pubmed:year
2003
pubmed:articleTitle
Patterns of cerebral inflammatory response in a rabbit model of intrauterine infection-mediated brain lesion.
pubmed:affiliation
Service de Néonatologie, Hôpital Mère-Enfant, 9 Quai Moncousu, CHRU, 44 093 Nantes 01, France. tdebillon@chu-grenoble.fr
pubmed:publicationType
Journal Article, Comparative Study