rdf:type |
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0023895,
umls-concept:C0185117,
umls-concept:C0205054,
umls-concept:C0205314,
umls-concept:C0332281,
umls-concept:C0439793,
umls-concept:C0678951,
umls-concept:C0679622,
umls-concept:C1337092,
umls-concept:C1522558,
umls-concept:C1705079,
umls-concept:C2911684
|
pubmed:issue |
4
|
pubmed:dateCreated |
2003-9-30
|
pubmed:abstractText |
Factors influencing the progression of chronic hepatitis C virus (HCV) infection are poorly understood. Monocyte chemotactic protein-1 (MCP-1) is a potent chemokine, and its hepatic expression is up-regulated during chronic HCV infection mainly in activated hepatic stellate cells (HSC). In this study, we investigated the correlation of the functional -2518 MCP-1 promoter polymorphism with hepatic MCP-1 expression and the disease outcome in patients with HCV.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0016-5085
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
125
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1085-93
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:14517792-Adult,
pubmed-meshheading:14517792-Chemokine CCL2,
pubmed-meshheading:14517792-Disease Progression,
pubmed-meshheading:14517792-Female,
pubmed-meshheading:14517792-Genetic Predisposition to Disease,
pubmed-meshheading:14517792-Genotype,
pubmed-meshheading:14517792-Hepatitis C, Chronic,
pubmed-meshheading:14517792-Humans,
pubmed-meshheading:14517792-Liver,
pubmed-meshheading:14517792-Liver Cirrhosis,
pubmed-meshheading:14517792-Male,
pubmed-meshheading:14517792-Middle Aged,
pubmed-meshheading:14517792-Phenotype,
pubmed-meshheading:14517792-Polymorphism, Genetic,
pubmed-meshheading:14517792-Retrospective Studies,
pubmed-meshheading:14517792-Severity of Illness Index
|
pubmed:year |
2003
|
pubmed:articleTitle |
A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease.
|
pubmed:affiliation |
Department of Internal Medicine I, University of Regensburg, Regensburg, Germany.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|