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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-9-30
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pubmed:abstractText |
Recent epidemiological studies have found that women infected with both herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) type 16 or HPV-18 are at greater risk of developing cervical carcinoma compared to women infected with only one virus. However, it remains unclear if HSV-2 is a cofactor for cervical cancer or if HPV and HSV-2 interact in any way. We have studied the effect of HSV-2 infection on HPV-11 gene expression in an in vitro double-infection assay. HPV transcripts were down-regulated in response to HSV-2 infection. Two HSV-2 vhs mutants failed to reduce HPV-16 E1;E4 transcripts. We also studied the effect of HSV-2 infection on preexisting experimental papillomas in a vaginal epithelial xenograft model. Doubly infected grafts demonstrated papillomatous transformation and the classical cytopathic effect from HSV-2 infection. HPV and HSV DNA signals were mutually exclusive. These studies may have therapeutic applications for HPV infections and related neoplasms.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0042-6822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
314
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
147-60
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:14517068-Animals,
pubmed-meshheading:14517068-Disease Models, Animal,
pubmed-meshheading:14517068-Down-Regulation,
pubmed-meshheading:14517068-Female,
pubmed-meshheading:14517068-Gene Expression Regulation, Viral,
pubmed-meshheading:14517068-Herpes Genitalis,
pubmed-meshheading:14517068-Herpesvirus 2, Human,
pubmed-meshheading:14517068-Humans,
pubmed-meshheading:14517068-Mice,
pubmed-meshheading:14517068-Mice, Nude,
pubmed-meshheading:14517068-Oncogene Proteins, Fusion,
pubmed-meshheading:14517068-Oncogene Proteins, Viral,
pubmed-meshheading:14517068-Papillomaviridae,
pubmed-meshheading:14517068-Papillomavirus Infections,
pubmed-meshheading:14517068-Repressor Proteins,
pubmed-meshheading:14517068-Ribonucleases,
pubmed-meshheading:14517068-Tissue Transplantation,
pubmed-meshheading:14517068-Transplantation, Heterologous,
pubmed-meshheading:14517068-Tumor Cells, Cultured,
pubmed-meshheading:14517068-Vagina,
pubmed-meshheading:14517068-Viral Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Suppression of human papillomavirus gene expression in vitro and in vivo by herpes simplex virus type 2 infection.
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pubmed:affiliation |
Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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