Linked Life Data

14515736

Source:http://linkedlifedata.com/resource/pubmed/id/14515736

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2003-9-30
pubmed:abstractText
Based on data from preclinical studies and anecdotal case reports in patients with co-existent autoimmune diseases, stem cell transplantation, mainly autologous transplantation, has been performed for patients with severs autoimmune diseases since the past decade. Initial results are encouraging despite controversies. In diseases, such as systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, and scleroderma, phase III trails are being designed. Careful selection of patients, mobilization regimens, graft manipulations, and conditioning regimens is the key in order to improve the outcome and avoid the toxicity. Allogeneic transplantation, on the other hand, is still in the initial stage of clinical study, but may be more effective in some diseases that are refractory to immunosuppressive therapies. Ongoing and future trials will prove the value of these approaches.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1643-54
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
[Autologous and allogeneic stem cell transplantation for severe autoimmune diseases].
pubmed:affiliation
Division of Immunotherapy, Northwestern University Medical School, USA.
pubmed:publicationType
Journal Article, English Abstract, Review