Linked Life Data

14514433

Source:http://linkedlifedata.com/resource/pubmed/id/14514433

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
2003-9-29
pubmed:abstractText
Carbon nanotubes are new members of carbon allotropes similar to fullerenes and graphite. Because of their unique electrical, mechanical, and thermal properties, carbon nanotubes are important for novel applications in the electronics, aerospace, and computer industries. Exposure to graphite and carbon materials has been associated with increased incidence of skin diseases, such as carbon fiber dermatitis, hyperkeratosis, and naevi. We investigated adverse effects of single-wall carbon nanotubes (SWCNT) using a cell culture of immortalized human epidermal keratinocytes (HaCaT). After 18 h of exposure of HaCaT to SWCNT, oxidative stress and cellular toxicity were indicated by formation of free radicals, accumulation of peroxidative products, antioxidant depletion, and loss of cell viability. Exposure to SWCNT also resulted in ultrastructural and morphological changes in cultured skin cells. These data indicate that dermal exposure to unrefined SWCNT may lead to dermal toxicity due to accelerated oxidative stress in the skin of exposed workers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1528-7394
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1909-26
pubmed:dateRevised
2006-2-16
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells.
pubmed:affiliation
Pathology and Physiology Research Branch, National Institute of Occupational Safety and Health, and Physiology and Pharmacology Department, West Virginia University, Morgantown 26505, USA. ats1@cdc.gov
pubmed:publicationType
Journal Article