Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1993-1-7
|
pubmed:abstractText |
1. Heme regulation before the appearance of hyperplastic nodules was investigated in mice models of hepatocarcinogenesis. 2. With this aim 5-aminolaevulinate synthetase (ALA-S), microsomal heme-oxygenase (MHO), mitochondrial and cytoplasmic rhodanese activities were examined throughout a period of 35 days in animals exposed to dietary p-dimethylaminoazobenzene (DAB). 3. ALA-S activity was significantly diminished (50%) on day 14, then showing a sharply rising profile from day 28 onwards, and reaching 350% on day 35. 4. A similar profile was observed for mitochondrial rhodanese activity. 5. Changes in MHO and cytoplasmic rhodanese activities were almost the opposite to those observed for ALA-S. 6. The distinctive alteration in mitochondrial and cytoplasmic rhodanese would suggest that it plays a subtle role in ALA-S regulation during carcinogenesis initiation through a mechanism that appears to involve subcellular localization controls perhaps by means of the breakage of cystine trisulphide postulated to act as an ALA-S activator. 7. Taking into account the present results, we suggest a probable mechanism for the onset of hepatocarcinogenesis that includes a primary activating liver status, provoking biochemical aberration leading to the stage of initiation of hepatocarcinogenesis involving the whole organ.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5-Aminolevulinate Synthetase,
http://linkedlifedata.com/resource/pubmed/chemical/Heme,
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase (Decyclizing),
http://linkedlifedata.com/resource/pubmed/chemical/Thiosulfate Sulfurtransferase,
http://linkedlifedata.com/resource/pubmed/chemical/p-Dimethylaminoazobenzene
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0305-0491
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
103
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
251-6
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:1451437-5-Aminolevulinate Synthetase,
pubmed-meshheading:1451437-Animals,
pubmed-meshheading:1451437-Cytoplasm,
pubmed-meshheading:1451437-Heme,
pubmed-meshheading:1451437-Heme Oxygenase (Decyclizing),
pubmed-meshheading:1451437-Kinetics,
pubmed-meshheading:1451437-Liver,
pubmed-meshheading:1451437-Liver Neoplasms, Experimental,
pubmed-meshheading:1451437-Male,
pubmed-meshheading:1451437-Mice,
pubmed-meshheading:1451437-Microsomes, Liver,
pubmed-meshheading:1451437-Mitochondria, Liver,
pubmed-meshheading:1451437-Thiosulfate Sulfurtransferase,
pubmed-meshheading:1451437-p-Dimethylaminoazobenzene
|
pubmed:year |
1992
|
pubmed:articleTitle |
Heme biosynthesis pathway regulation in a model of hepatocarcinogenesis pre-initiation.
|
pubmed:affiliation |
Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET y FCEN, UBA, Ciudad Universitaria, Republic of Argentina.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|