Linked Life Data

1451313

Source:http://linkedlifedata.com/resource/pubmed/id/1451313

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-1-6
pubmed:abstractText
A double-blind study has been carried out in 12 normal volunteer subjects in order to determine the relative irritancy of povidone-iodine solutions. Aqueous solutions of 10% povidone-iodine (PI), standardized 10% povidone-iodine (SPI) and reformulated standardized 10% povidone-iodine (RSPI) were applied to the backs and occluded using aluminium chambers. At 1, 2, 3, 4, 5, 6, and 8 hours, chambers were removed and the degree of cutaneous irritancy assessed. As well as subjective assessment of erythema, objective measurement of skin colour was performed using an erythema meter. In addition, laser Doppler blood-flow measurements have been carried out. The results show a rapid increase in cutaneous irritancy as evidenced by an increase in visual scores of erythema, increased erythema meter readings and increased cutaneous blood-flow. The increase was greatest for SPI treated sites for all three methods. Statistically these differences were significant at P < 0.05. Thus in this controlled study it has been possible to discriminate between the similar formulations in terms of their cutaneous irritancy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0307-6938
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
246-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
An evaluation of the irritancy potential of povidone iodine solutions: comparison of subjective and objective assessment techniques.
pubmed:affiliation
Department of Dermatology, University of Wales College of Medicine, Cardiff.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Controlled Clinical Trial, Research Support, Non-U.S. Gov't