Linked Life Data

14512096

Source:http://linkedlifedata.com/resource/pubmed/id/14512096

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-9-26
pubmed:abstractText
In order to determine whether a non-exocytotic mechanism was involved in ethanol-induced in vivo dopamine release in the nucleus accumbens, extracellular dopamine concentrations were measured via intracerebral microdialysis in freely moving Sprague-Dawley rats. Effects of ethanol on dopamine release in the nucleus accumbens were compared with those by cocaine, a drug that increases synaptic dopamine by a mechanism, which depends on neuronal activity and involves an exocytotic process. Administration of ethanol (80 mM) or cocaine (10 microM) via a dialysis probe increased extracellular dopamine concentrations in the nucleus accumbens. Pretreatments with tetrodotoxin (2 microM) or Ca2+ withdrawal did not block the ability of ethanol to increase nucleus accumbens dopamine. The blockade of dopamine autoreceptors by local infusion of sulpiride did not significantly alter the effect of ethanol on nucleus accumbens dopamine either. As opposed to ethanol, however, cocaine-induced increases in nucleus accumbens dopamine were sensitive to tetrodotoxin or Ca2+ omission. In addition, pretreatments with sulpiride significantly potentiated the effect of cocaine on extracellular dopamine concentrations. These differences in responses to tetrodotoxin, Ca2+ withdrawal and inhibition of dopamine autoreceptors suggest that a non-exocytotic mechanism may be involved in dopamine release in the nucleus accumbens evoked by focally applied ethanol.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
477
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-44
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Involvement of non-exocytotic mechanisms in ethanol-induced in vivo dopamine release: comparisons with cocaine.
pubmed:affiliation
Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine at Peoria, Peoria, IL 61656, USA. QSY@UIC.EDU
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.