Linked Life Data

14511072

Source:http://linkedlifedata.com/resource/pubmed/id/14511072

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-9-26
pubmed:abstractText
1. Inflammatory bowel disease (IBD) is a condition that involves proinflammatory cytokines such as interleukins 1beta and 6 (ILs). In this disease, it has been shown that an abnormal microcirculatory system is implicated. 2. Therefore, the effects of in vivo treatment for three days with interleukins 1beta and 6 were investigated on rat isolated mesenteric vascular bed (MVB). 3. A significant concentration-dependent increase in vascular response to noradrenaline (NA) was found, with a significant difference in Emax between control (93.01 +/- 16.78 mmHg) and treated preparations (137.91 +/- 5.20 mmHg). Endothelin-1(ET-1) induced a significantly greater increase of perfusion pressure in treated rats in comparison with control rats at the highest concentration used (0.1 microm). 4. The concentration-dependent decrease of perfusion pressure induced by acetylcholine (ACh) in MVB precontracted with NA was significantly reduced in specimens from treated rats in comparison with control rats, with a significant difference in Emax between control and treated preparations. 5. Perivascular nerve stimulation (PNS) evoked contractions with no difference between treatments. Similarly, no difference in relaxant effect was found after PNS in specimens precontracted with NA, in the presence of guanethidine. 6. These findings indicate that the precocious inflammation acts only at postsynaptic level, facilitating vascular contraction. These data seem to support the hypothesis that vascular dysfunction caused by overproduction of ILs may contribute, among other immunological factors, to vasculitis in IBD that leads to intestinal ischaemia through vasoconstriction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1474-8665
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
125-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:14511072-Acetylcholine, pubmed-meshheading:14511072-Animals, pubmed-meshheading:14511072-Arginine, pubmed-meshheading:14511072-Disease Models, Animal, pubmed-meshheading:14511072-Dose-Response Relationship, Drug, pubmed-meshheading:14511072-Drug Synergism, pubmed-meshheading:14511072-Electric Stimulation, pubmed-meshheading:14511072-Endothelin-1, pubmed-meshheading:14511072-Fever, pubmed-meshheading:14511072-Guanethidine, pubmed-meshheading:14511072-Inflammation, pubmed-meshheading:14511072-Interleukin-1, pubmed-meshheading:14511072-Interleukin-6, pubmed-meshheading:14511072-Intestinal Mucosa, pubmed-meshheading:14511072-Isomerism, pubmed-meshheading:14511072-Isoproterenol, pubmed-meshheading:14511072-Male, pubmed-meshheading:14511072-Mesenteric Arteries, pubmed-meshheading:14511072-NG-Nitroarginine Methyl Ester, pubmed-meshheading:14511072-Norepinephrine, pubmed-meshheading:14511072-Perfusion, pubmed-meshheading:14511072-Rats, pubmed-meshheading:14511072-Rats, Sprague-Dawley, pubmed-meshheading:14511072-Sumatriptan, pubmed-meshheading:14511072-Time Factors, pubmed-meshheading:14511072-Vascular Resistance, pubmed-meshheading:14511072-Vasoconstriction, pubmed-meshheading:14511072-Vasodilation
pubmed:year
2003
pubmed:articleTitle
Effects of in vivo treatment with interleukins 1beta and 6 on rat mesenteric vascular bed reactivity.
pubmed:affiliation
Department of Pharmacology and Human Physiology, Medical School, University of Bari, Piazza G. Cesare, 70124 Bari, Italy.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't