14510504

Source:http://linkedlifedata.com/resource/pubmed/id/14510504

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0002045, umls-concept:C0015219, umls-concept:C0021469, umls-concept:C0075813, umls-concept:C0220908, umls-concept:C1567953
pubmed:issue	3
pubmed:dateCreated	2003-9-26
pubmed:abstractText	We have developed a novel method for screening DNA aptamers by an algorithm mimicking evolution, which have enabled selection by not affinity but inhibitory activity of aptamers. Using this method, we have successfully obtained DNA aptamers that inhibit Taq DNA polymerase in a few hundred-nanomolar range. This result shows this method would be useful for screening aptamers as an enzyme inhibitor.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101169367
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/DNA, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Taq Polymerase
pubmed:status	MEDLINE
pubmed:author	pubmed-author:IkebukuroKazunoriK, pubmed-author:NomaTakahisaT
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	309-10
pubmed:dateRevised	2006-11-30
pubmed:meshHeading	pubmed-meshheading:14510504-Algorithms, pubmed-meshheading:14510504-DNA, pubmed-meshheading:14510504-Enzyme Inhibitors, pubmed-meshheading:14510504-Evolution, Molecular, pubmed-meshheading:14510504-Taq Polymerase
pubmed:year	2003
pubmed:articleTitle	Screening of DNA aptamers inhibiting Taq DNA polymerase using algorithm mimicking evolution.
pubmed:affiliation	Department of Biotechnology & Life Science, Tokyo University of Agriculture & Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
pubmed:publicationType	Journal Article