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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1993-1-7
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pubmed:abstractText |
Recent evidence suggests that muscarinic receptors play a role in the hippocampal hypersensitivity to imposed ischemia following mild traumatic brain injury (TBI). In rat hippocampal tissue, carbachol-stimulated inositol phosphate production was found to be enhanced by mild TBI, at 1 h post injury. This finding suggests that mild TBI may result in enhanced coupling between muscarinic receptors and phosphoinositide hydrolysis, which may contribute to post-traumatic hippocampal vulnerability to secondary ischemia.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
594
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
307-10
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1450957-Animals,
pubmed-meshheading:1450957-Brain Injuries,
pubmed-meshheading:1450957-Brain Ischemia,
pubmed-meshheading:1450957-Carbachol,
pubmed-meshheading:1450957-Hippocampus,
pubmed-meshheading:1450957-Inositol Phosphates,
pubmed-meshheading:1450957-Male,
pubmed-meshheading:1450957-Rats,
pubmed-meshheading:1450957-Rats, Wistar,
pubmed-meshheading:1450957-Receptors, Muscarinic
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pubmed:year |
1992
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pubmed:articleTitle |
Mild traumatic brain injury enhances muscarinic receptor-linked inositol phosphate production in rat hippocampus.
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pubmed:affiliation |
Division of Neurosurgery, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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