Linked Life Data

14506980

Source:http://linkedlifedata.com/resource/pubmed/id/14506980

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
2003-9-24
pubmed:abstractText
The control of coagulation factor levels has a pivotal role in thrombophilia and known functional polymorphisms explain only a minor part of the coagulation factor level variance. Several studies provide evidence for i) interaction of polymorphisms and their combination with environmental factors; ii) molecular mechanisms mediating activation of coagulation proteins by environmental factors; iii) molecular mechanisms mediating transcriptional control of thrombophilia genes by environmental factors. However, the vast majority of molecular regulation by environmental factors is still unknown. Understanding of gene-gene and gene-environment interactions will require a detailed knowledge of regulatory regions of thrombophilia genes and of regulatory proteins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1424-8832
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
335-7
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Modulation of thrombophilia genes by environmental factors.
pubmed:affiliation
Dipartimento di Biochimica e Biologia Molecolare, Università degli Studi di Ferrara, Ferrara, Italy. ber@unife.it
pubmed:publicationType
Journal Article, Review