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pubmed-article:14506399pubmed:abstractTextIncreased mean corpuscular volume (MCV) is common in alcohol abusers and alcoholics. MCV is higher in Japanese heavy drinkers with inactive aldehyde dehydrogenase-2 (ALDH2) encoded by ALDH2*1/2*2 than among those with active ALDH2 encoded by ALDH2*1/2*1. Inactive ALDH2 dramatically increases blood acetaldehyde levels after alcohol intake. Because moderate and heavy drinkers with ALDH2*1/2*2 have very high risks for esophageal cancer, MCV might serve as an indicator of these high-risk drinkers.lld:pubmed
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pubmed-article:14506399pubmed:articleTitleMean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers.lld:pubmed
pubmed-article:14506399pubmed:affiliationMitsukoshi Health and Welfare Foundation, Tokyo, Japan.lld:pubmed
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