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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2003-9-24
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pubmed:abstractText |
Increased mean corpuscular volume (MCV) is common in alcohol abusers and alcoholics. MCV is higher in Japanese heavy drinkers with inactive aldehyde dehydrogenase-2 (ALDH2) encoded by ALDH2*1/2*2 than among those with active ALDH2 encoded by ALDH2*1/2*1. Inactive ALDH2 dramatically increases blood acetaldehyde levels after alcohol intake. Because moderate and heavy drinkers with ALDH2*1/2*2 have very high risks for esophageal cancer, MCV might serve as an indicator of these high-risk drinkers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0145-6008
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1395-401
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14506399-Adult,
pubmed-meshheading:14506399-Age Factors,
pubmed-meshheading:14506399-Alcohol Drinking,
pubmed-meshheading:14506399-Alcoholism,
pubmed-meshheading:14506399-Aldehyde Dehydrogenase,
pubmed-meshheading:14506399-Asian Continental Ancestry Group,
pubmed-meshheading:14506399-Body Mass Index,
pubmed-meshheading:14506399-Erythrocyte Indices,
pubmed-meshheading:14506399-Esophageal Neoplasms,
pubmed-meshheading:14506399-Food Habits,
pubmed-meshheading:14506399-Genetic Markers,
pubmed-meshheading:14506399-Genetic Predisposition to Disease,
pubmed-meshheading:14506399-Genotype,
pubmed-meshheading:14506399-Hong Kong,
pubmed-meshheading:14506399-Humans,
pubmed-meshheading:14506399-Male,
pubmed-meshheading:14506399-Middle Aged,
pubmed-meshheading:14506399-Multivariate Analysis,
pubmed-meshheading:14506399-Reference Values,
pubmed-meshheading:14506399-Risk Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers.
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pubmed:affiliation |
Mitsukoshi Health and Welfare Foundation, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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