Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
45
pubmed:dateCreated
2003-11-3
pubmed:abstractText
Nuclear receptor-mediated gene expression is proposed to be regulated by the ordered recruitment of large protein complexes in which activity depends on mutual interactions and posttranslational modifications. In contrast, relatively little attention has been given to mechanisms regulating the expression of the coregulator proteins themselves. Previously we have shown that the ligand-dependent corepressor, RIP140, is a direct transcriptional target of all-trans retinoic acid (RA). Here we demonstrate that RA induction of RIP140 constitutes a rate-limiting step in the regulation of retinoic acid receptor signaling. Silencing of the RA induction of RIP140 dramatically enhances and accelerates retinoid receptor transactivation, endogenous expression of other RA target genes, and RA-induced neuronal differentiation and cell cycle arrest in human embryonal carcinoma cells. The data suggest that RA induction of RIP140 constitutes a functional negative feedback loop that limits activation of retinoid receptors in the continued presence of RA and that acutely regulated expression of coregulators may be a general regulatory mechanism in hormonal signaling.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System, http://linkedlifedata.com/resource/pubmed/chemical/LEFTY1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Left-Right Determination Factors, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta, http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin, http://linkedlifedata.com/resource/pubmed/chemical/nuclear receptor interacting..., http://linkedlifedata.com/resource/pubmed/chemical/retinoic acid 4-hydroxylase, http://linkedlifedata.com/resource/pubmed/chemical/retinoic acid binding protein II..., http://linkedlifedata.com/resource/pubmed/chemical/retinoic acid receptor beta
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
278
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43889-92
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:14506269-Adaptor Proteins, Signal Transducing, pubmed-meshheading:14506269-Carcinoma, Embryonal, pubmed-meshheading:14506269-Cell Cycle, pubmed-meshheading:14506269-Cell Differentiation, pubmed-meshheading:14506269-Cell Line, pubmed-meshheading:14506269-Cell Nucleus, pubmed-meshheading:14506269-Cytochrome P-450 Enzyme System, pubmed-meshheading:14506269-Feedback, Physiological, pubmed-meshheading:14506269-G1 Phase, pubmed-meshheading:14506269-Gene Expression Regulation, pubmed-meshheading:14506269-Humans, pubmed-meshheading:14506269-Left-Right Determination Factors, pubmed-meshheading:14506269-Neurons, pubmed-meshheading:14506269-Nuclear Proteins, pubmed-meshheading:14506269-RNA, Messenger, pubmed-meshheading:14506269-RNA, Small Interfering, pubmed-meshheading:14506269-Receptors, Retinoic Acid, pubmed-meshheading:14506269-Signal Transduction, pubmed-meshheading:14506269-Transcriptional Activation, pubmed-meshheading:14506269-Transfection, pubmed-meshheading:14506269-Transforming Growth Factor beta, pubmed-meshheading:14506269-Tretinoin
pubmed:year
2003
pubmed:articleTitle
Negative feedback at the level of nuclear receptor coregulation. Self-limitation of retinoid signaling by RIP140.
pubmed:affiliation
Department of Pharmacology and Toxicology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Hanover, New Hampshire 03755, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't