Source:http://linkedlifedata.com/resource/pubmed/id/14505669
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
20
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| pubmed:dateCreated |
2003-9-24
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| pubmed:abstractText |
Several members of the 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones (2) have been identified as being potent and selective NMDA glycine-site antagonists. Increasing size of the alkyl substituent on the alpha-carbon led to a progressive decrease in binding affinity. Some of these analogues possess improved drug-like properties such as cellular permeability, solubility and oral absorption.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
|
| pubmed:issn |
0960-894X
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| pubmed:author |
pubmed-author:BareThomas MTM,
pubmed-author:BrownDean GDG,
pubmed-author:DyroffMartin CMC,
pubmed-author:EmpfieldJames RJR,
pubmed-author:ForstJanet MJM,
pubmed-author:HerzogKeith JKJ,
pubmed-author:HorchlerCarey LCL,
pubmed-author:KeithRichard ARA,
pubmed-author:LeeChi-Ming CCM,
pubmed-author:McLarenFrances MFM,
pubmed-author:MurphyMeganM,
pubmed-author:NeilsonKathy LKL,
pubmed-author:SteelmanGary BGB,
pubmed-author:TrivediShephaliS,
pubmed-author:UrbanekRebecca ARA,
pubmed-author:XiaoWenhuaW
|
| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3553-6
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| pubmed:meshHeading | |
| pubmed:year |
2003
|
| pubmed:articleTitle |
Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones as NMDA glycine-site antagonists.
|
| pubmed:affiliation |
AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE 19850, USA. dean.brown@astrazeneca.com
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| pubmed:publicationType |
Journal Article
|