Source:http://linkedlifedata.com/resource/pubmed/id/14505351
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2003-9-23
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| pubmed:abstractText |
We studied the beneficial effects of dietary consumption of n-3 polyunsaturated fatty acids (PUFA) and two selective estrogen receptor modulator (SERM) derivatives (SERM-I and SERM-II) and their combined effect on serum lipids, skin dermis and adipose layers, bone marrow adipogenesis, and cytokine secretion in mice. Two different ovariectomized (OVX) models were studied: treatment began immediately post-OVX in one and 3 months post-OVX in the other. Our results showed that n-3 PUFA and both SERMs decreased triglyceride levels in the serum, and that SERMs also decreased serum cholesterol levels while n-3 PUFA had no similar effect. SERMs had no effect on IL-6, IL-1 beta, or IL-10 levels, but they decreased ex vivo tumor necrosis factor (TNF-alpha). N-3 PUFA decreased secretion of non-induced IL-6 and TNF-alpha from cultured BMC and IL-1 beta levels in vivo (i.e., in bone marrow plasma), but its main effect was a significant elevation in the secretion of IL-10, a known anti-inflammatory cytokine. OVX-induced B-lymphopoiesis was not affected by LY-139481 (SERM-I) while LY-353381 (SERM-II) exhibited an estrogen-antagonistic effect in sham and OVX mice and elevated the amount of B-cells in bone marrow. Fish oil consumption prevented the elevation in B-lymphopoiesis caused by OVX, but had no curative effect on established augmented B-lymphopoiesis. This activity could be mediated via the elevation of IL-10 which was shown to suppress B-lymphopoiesis. Both SERMs and n-3 PUFA inhibited the increase in adipose tissue thickness caused by OVX in mice. Our results showed that n-3 PUFA, could prevent some of the deleterious outcomes of estrogen deficiency that were not affected by SERMs. We observed no significant beneficial effects of the combined administration of SERM-I, SERM-II, and PUFA on the studied parameters.The exact mechanism by which polyunsaturated fatty acids exert their activities is still not clear, but peroxisome proliferator-activated receptors (PPARs) might be involved in processes which are modulated by n-3 PUFA.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Omega-3,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Fish Oils,
http://linkedlifedata.com/resource/pubmed/chemical/Hypolipidemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/LY 353381,
http://linkedlifedata.com/resource/pubmed/chemical/Pikasol,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Raloxifene,
http://linkedlifedata.com/resource/pubmed/chemical/Selective Estrogen Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Thiophenes,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0730-2312
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
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| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
90
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
347-60
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:14505351-Adipose Tissue,
pubmed-meshheading:14505351-Animals,
pubmed-meshheading:14505351-Body Weight,
pubmed-meshheading:14505351-Bone Marrow Cells,
pubmed-meshheading:14505351-Cholesterol,
pubmed-meshheading:14505351-Fatty Acids, Omega-3,
pubmed-meshheading:14505351-Fatty Acids, Unsaturated,
pubmed-meshheading:14505351-Female,
pubmed-meshheading:14505351-Fish Oils,
pubmed-meshheading:14505351-Hypolipidemic Agents,
pubmed-meshheading:14505351-Interleukin-1,
pubmed-meshheading:14505351-Interleukin-10,
pubmed-meshheading:14505351-Interleukin-6,
pubmed-meshheading:14505351-Mice,
pubmed-meshheading:14505351-Mice, Inbred BALB C,
pubmed-meshheading:14505351-Ovariectomy,
pubmed-meshheading:14505351-Ovary,
pubmed-meshheading:14505351-Piperidines,
pubmed-meshheading:14505351-Raloxifene,
pubmed-meshheading:14505351-Selective Estrogen Receptor Modulators,
pubmed-meshheading:14505351-Skin,
pubmed-meshheading:14505351-Spleen,
pubmed-meshheading:14505351-Thiophenes,
pubmed-meshheading:14505351-Triglycerides,
pubmed-meshheading:14505351-Tumor Necrosis Factor-alpha
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| pubmed:year |
2003
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| pubmed:articleTitle |
Effects of long-term administration of N-3 polyunsaturated fatty acids (PUFA) and selective estrogen receptor modulator (SERM) derivatives in ovariectomized (OVX) mice.
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| pubmed:affiliation |
Department of Pediatric Orthopaedics, Dana Children's Hospital, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Israel. pedorth@tasmc.health.gov.il
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| pubmed:publicationType |
Journal Article
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