Source:http://linkedlifedata.com/resource/pubmed/id/14504446
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0001675,
umls-concept:C0013030,
umls-concept:C0034493,
umls-concept:C0035696,
umls-concept:C0178784,
umls-concept:C0205263,
umls-concept:C0221464,
umls-concept:C0242184,
umls-concept:C0392747,
umls-concept:C0441889,
umls-concept:C0443172,
umls-concept:C0443199,
umls-concept:C1704259,
umls-concept:C1705987
|
| pubmed:issue |
3
|
| pubmed:dateCreated |
2003-9-23
|
| pubmed:abstractText |
This study determined: (1) whether dopamine (DA) D2-receptor (R) and D1-R mRNA levels in the carotid body (CB), petrosal ganglion (PG) and superior cervical ganglion (SCG) are modulated by hypoxia; (2) the role of hypoxia intensity and exposure duration, and (3) whether the pattern of modulation differs between newborn (1-day-old) and adult rabbits. Rabbits were exposed to five FiO2 conditions: 21% (control); 15%/6 h; 15%/24 h; 8%/6 h and 8%/24 h. D2- and D1-R mRNA expression levels were calculated for each hypoxia condition relative to control using RT-PCR analysis. In the CB of 1-day-old rabbits, D2- and D1-R transcript levels increased and decreased after exposure to 15 and 8% O2, respectively. In the adult CB, D2- and D1-R transcript levels decreased independently of hypoxia intensities. Only changes in D1-R mRNA levels were dependent on exposure time. In the PG, both hypoxia intensities decreased the D2-R transcript levels in 1-day-old and adult rabbits; but for the D1-R mRNA levels, hypoxia decreased its level in 1-day-old rabbits and increased it in adults regardless of exposure duration. In the SCG, hypoxia had no determinant effect on the D2-R mRNA levels either in newborn or adult rabbits while it induced a decrease of D1-R transcript levels in 1-day-old rabbits and an increase in adult rabbits. It is concluded that hypoxia affects DA D2- or D1-R mRNA levels in the chemoreflex pathway in an age-dependent and site-specific manner.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0006-3126
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2003 S. Karger AG, Basel
|
| pubmed:issnType |
Print
|
| pubmed:volume |
84
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
222-31
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:14504446-Aging,
pubmed-meshheading:14504446-Animals,
pubmed-meshheading:14504446-Animals, Newborn,
pubmed-meshheading:14504446-Anoxia,
pubmed-meshheading:14504446-Arteries,
pubmed-meshheading:14504446-Carotid Body,
pubmed-meshheading:14504446-Chemoreceptor Cells,
pubmed-meshheading:14504446-Corpus Striatum,
pubmed-meshheading:14504446-Dose-Response Relationship, Drug,
pubmed-meshheading:14504446-Drug Administration Schedule,
pubmed-meshheading:14504446-Ganglia, Sensory,
pubmed-meshheading:14504446-Oxygen,
pubmed-meshheading:14504446-RNA, Messenger,
pubmed-meshheading:14504446-Rabbits,
pubmed-meshheading:14504446-Receptors, Dopamine D1,
pubmed-meshheading:14504446-Receptors, Dopamine D2,
pubmed-meshheading:14504446-Reflex,
pubmed-meshheading:14504446-Superior Cervical Ganglion
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Differential changes in dopamine D2- and D1-receptor mRNA levels induced by hypoxia in the arterial chemoreflex pathway organs in one-day-old and adult rabbits.
|
| pubmed:affiliation |
Unité de recherche en périnatologie, Centre Hospitalier Universitaire de Québec, Hôpital Saint-François-d'Assise, Université Laval, Québec, Canada. Aida.Bairam@crsfa.ulaval.ca
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|