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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2003-9-23
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pubmed:abstractText |
Several trials have demonstrated that the response proportions to microtubule agents in patients with prostate cancer are increased by the addition of estramustine phosphate (EMP). The epothilone B analog BMS-247550 is a novel microtubule agent that has shown activity in taxane-resistant tumors. We conducted a dose-escalation study to determine a safe dose of BMS-247550 to combine with EMP in patients with metastatic prostate cancer.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0923-7534
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1518-24
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14504052-Adenocarcinoma,
pubmed-meshheading:14504052-Adult,
pubmed-meshheading:14504052-Antineoplastic Agents,
pubmed-meshheading:14504052-Antineoplastic Agents, Hormonal,
pubmed-meshheading:14504052-Bone Neoplasms,
pubmed-meshheading:14504052-Castration,
pubmed-meshheading:14504052-Dose-Response Relationship, Drug,
pubmed-meshheading:14504052-Epothilones,
pubmed-meshheading:14504052-Estramustine,
pubmed-meshheading:14504052-Humans,
pubmed-meshheading:14504052-Male,
pubmed-meshheading:14504052-Maximum Tolerated Dose,
pubmed-meshheading:14504052-Microtubules,
pubmed-meshheading:14504052-Middle Aged,
pubmed-meshheading:14504052-Prostate-Specific Antigen,
pubmed-meshheading:14504052-Prostatic Neoplasms,
pubmed-meshheading:14504052-Treatment Outcome
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pubmed:year |
2003
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pubmed:articleTitle |
Pilot study of epothilone B analog (BMS-247550) and estramustine phosphate in patients with progressive metastatic prostate cancer following castration.
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pubmed:affiliation |
Department of Medicine, Division of Solid Tumor, Memorial Sloan-Kettering Cancer Center, Joan and Sanford I. Weill Medical College of Cornell University, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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