Source:http://linkedlifedata.com/resource/pubmed/id/14502845
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2003-9-23
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| pubmed:abstractText |
Protective effects of an aged garlic extract on the cardiotoxicity of doxorubicin (DOX) was evaluated using the mouse. DOX (1.5 mg/kg body wt i.p.) was administered three times per week for 40 days. An aged garlic extract, WG-1 (a preserved stock solution; Wakunaga Pharmaceutical) was administered intraperitoneally six times weekly. DOX caused changes in the electrocardiogram. In the control mice, the width of the QRS complex was 20 +/- 2.8 milliseconds, the R-R interval was 130 +/- 2.8 milliseconds, and the P-Q interval was 30 +/- 1.4 milliseconds. In mice treated with DOX for 40 days, the width of the QRS complex was 50 +/- 10 milliseconds (p < 0.05), the R-R interval was 240 +/- 30 milliseconds (p < 0.05), and the P-Q interval was 45 +/- 1.0 milliseconds (p < 0.01). These values were significantly smaller in mice treated with WG-1 + DOX than in mice treated with DOX. The width of the QRS complex was 29.3 +/- 5.8 milliseconds (p < 0.05), the R-R interval was 145.8 +/- 17.9 milliseconds (p < 0.01), and the P-Q interval was 37.8 +/- 3.5 milliseconds (p < 0.05). The lipid peroxidation in the heart homogenates prepared from DOX-treated mice, as measured by thiobarbituric acid-reactive substance (TBARS, nmol malondialdehyde/100 mg protein) was 332.5 +/- 67.0, which was significantly larger than that in the control mice (186.6 +/- 42.2) (p < 0.05). WG-1 decreased the level of TBARS in DOX-treated mice significantly. In the mice treated with WG-1 + DOX, TBARS was 221.3 +/- 31.6, which was significantly smaller than that of DOX-treated mice (p < 0.05). Histological study demonstrated that the heart treated with DOX had vacuolization in muscle cells, disrupted myofibrils, and swollen mitochondria. Mice that received WG-1 + DOX had no significant pathological lesions in the heart.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0163-5581
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
163-73
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:14502845-Animals,
pubmed-meshheading:14502845-Antibiotics, Antineoplastic,
pubmed-meshheading:14502845-Body Weight,
pubmed-meshheading:14502845-Doxorubicin,
pubmed-meshheading:14502845-Electrocardiography,
pubmed-meshheading:14502845-Garlic,
pubmed-meshheading:14502845-Heart,
pubmed-meshheading:14502845-Heart Diseases,
pubmed-meshheading:14502845-Injections, Intraperitoneal,
pubmed-meshheading:14502845-Lipid Peroxidation,
pubmed-meshheading:14502845-Male,
pubmed-meshheading:14502845-Mice,
pubmed-meshheading:14502845-Mice, Inbred BALB C,
pubmed-meshheading:14502845-Myocardium,
pubmed-meshheading:14502845-Plant Extracts,
pubmed-meshheading:14502845-Random Allocation,
pubmed-meshheading:14502845-Survival Analysis,
pubmed-meshheading:14502845-Thiobarbituric Acid Reactive Substances
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| pubmed:year |
1994
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| pubmed:articleTitle |
Protective effects of an aged garlic extract on doxorubicin-induced cardiotoxicity in the mouse.
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| pubmed:affiliation |
Philadelphia Biomedical Research Institute, King of Prussia, PA 19406, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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