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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-9-22
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pubmed:abstractText |
To study the development of the atria, we produced a transgenic mouse line that expresses Cre under the regulatory control of a 7 kbp fragment of the Natriuretic peptide precursor type A gene (Nppa), from -3 kbp to +4 kbp relative to the transcription start site. Crossing this line with the R26R and Z/EG reporter lines revealed recombinase activity specifically in the cardiomyocytes of the atria and to a lesser extent the inflow tract from E10.5 onwards. At E14.5 recombination in the atria is almost complete. No recombination was observed outside the heart. These mice provide a tool to study gene function in the atria.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1526-954X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14502570-Animals,
pubmed-meshheading:14502570-Cell Line,
pubmed-meshheading:14502570-Genes, Reporter,
pubmed-meshheading:14502570-Heart Atria,
pubmed-meshheading:14502570-Heterozygote,
pubmed-meshheading:14502570-Integrases,
pubmed-meshheading:14502570-Mice,
pubmed-meshheading:14502570-Mice, Transgenic,
pubmed-meshheading:14502570-Microscopy, Fluorescence,
pubmed-meshheading:14502570-Models, Genetic,
pubmed-meshheading:14502570-Myocytes, Cardiac,
pubmed-meshheading:14502570-Natriuretic Agents,
pubmed-meshheading:14502570-Natriuretic Peptide, C-Type,
pubmed-meshheading:14502570-Protein Precursors,
pubmed-meshheading:14502570-Recombination, Genetic,
pubmed-meshheading:14502570-Time Factors,
pubmed-meshheading:14502570-Viral Proteins,
pubmed-meshheading:14502570-beta-Galactosidase
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pubmed:year |
2003
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pubmed:articleTitle |
Atrial cardiomyocyte-specific expression of Cre recombinase driven by an Nppa gene fragment.
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pubmed:affiliation |
Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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