Linked Life Data

14502259

Source:http://linkedlifedata.com/resource/pubmed/id/14502259

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-9-22
pubmed:abstractText
T(11;18)(q21;q21) occurs at variable frequencies in mucosa-associated lymphoid tissue (MALT) lymphomas of different sites. In gastric MALT lymphoma, it occurs in 30% cases and the translocation positive tumours are frequently at advanced stages and do not respond to Helicobacter pylori eradication. Intriguingly, t(11;18)(q21;q21) has been observed only rarely in mucosal diffuse large B-cell lymphomas (DLBCL), despite that at least a proportion of these tumours are believed to be the result of transformation of an MALT lymphoma. We previously examined t(11;18)(q21;q21) in gastric MALT lymphoma of Chinese in Taiwan and found the translocation in one of the three transformed MALT lymphomas studied. To extend this observation, we have examined t(11;18)(q21;q21) in a large cohort of gastric lymphomas of Chinese in China including 39 MALT lymphomas (12 with high-grade components) and 53 DLBCL by reverse transcription and PCR. Of these cases, RNA samples extracted from 36 MALT lymphomas including 10 cases with high-grade component and 46 DLBCL were adequate for detection of the translocation as judged by control RT-PCR of a house-keeping gene. T(11;18)(q21;q21) was found in 8/36 (22%) MALT lymphomas and 1/46 (2%) DLBCL. None of the MALT lymphoma with high-grade component showed t(11;18)(q21;q21). Our results suggest that t(11;18)(q21;q21) occurs only occasionally in transformed MALT lymphoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1466-4860
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
342-5
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
T(11;18)(q21;q21) in gastric MALT lymphoma and diffuse large B-cell lymphoma of Chinese patients.
pubmed:affiliation
Department of Histopathology, University College London, London, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't