Linked Life Data

14501050

Source:http://linkedlifedata.com/resource/pubmed/id/14501050

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-9-22
pubmed:abstractText
A large body of in vitro studies has helped to elucidate intracellular pathways that lead to mitogenic signaling in vascular smooth muscle (VSM) cells. However, a limitation of these studies is that they fail to test the in vivo physiological significance especially because VSM proliferation, in the forms of intimal hyperplasia and restenosis, is an important clinical problem. The recent advent of adenoviral gene transfer technology has made possible to test the in vivo effects of specific molecular modulations of intracellular signal transduction pathways on physiological responses. For example, in VSM, adenoviruses can be delivered to the vessel wall to determine a gene/protein's role in proliferative responses to vascular injury. This technology, once standardized and rendered safe for human applications, will be the basis of gene therapy and molecular medicine. Several exemplary applications have now been generated in the vascular system, including the use of an adenovirus containing the carboxyl-terminus of the beta-adrenergic receptor kinase (beta ARKct), which binds to the beta gamma-subunits of activated heterotrimeric G proteins (G beta gamma), to study the in vivo role of G beta gamma in VSM intimal hyperplasia after vascular injury that leads to restenosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1064-3745
pubmed:author
pubmed:issnType
Print
pubmed:volume
237
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
181-92
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
In vivo adenoviral-mediated gene transfer of the beta ARKct to study the role of G beta gamma in arterial restenosis.
pubmed:affiliation
Dipartmento di Medicina Clinica, Scienze Cardiovasculari ed Immunologiche, Federico II University, Naples, Italy.
pubmed:publicationType
Journal Article, Review