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rdf:type |
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lifeskim:mentions |
umls-concept:C0006104,
umls-concept:C0032433,
umls-concept:C0085732,
umls-concept:C0085828,
umls-concept:C0442805,
umls-concept:C0521447,
umls-concept:C0591833,
umls-concept:C1148673,
umls-concept:C1159467,
umls-concept:C1264633,
umls-concept:C1707520,
umls-concept:C1883525,
umls-concept:C2346866
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|
pubmed:issue |
1
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pubmed:dateCreated |
2003-9-22
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pubmed:abstractText |
The addition of a number of natural and synthetic polyamines significantly increased activator protein (AP1) DNA binding in nuclear extracts of murine whole brain, which occurred in a manner positively correlated with their potencies to inhibit temperature-dependent transport of [3H]spermidine in brain nuclear fractions. These results suggest that polyamines may affect gene transcription by AP1 complex after incorporation into the nucleus in rodent brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
987
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
126-30
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14499955-Animals,
pubmed-meshheading:14499955-Biological Transport,
pubmed-meshheading:14499955-Brain,
pubmed-meshheading:14499955-Cell Nucleus,
pubmed-meshheading:14499955-DNA,
pubmed-meshheading:14499955-Gene Expression Regulation,
pubmed-meshheading:14499955-Male,
pubmed-meshheading:14499955-Mice,
pubmed-meshheading:14499955-Polyamines,
pubmed-meshheading:14499955-Spermidine,
pubmed-meshheading:14499955-Transcription Factor AP-1,
pubmed-meshheading:14499955-Tritium
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pubmed:year |
2003
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pubmed:articleTitle |
Possible correlation between abilities of a variety of polyamines to increase activator protein-1 DNA binding and to inhibit [3H]spermidine transport in nuclear fractions of murine brain.
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pubmed:affiliation |
Kanazawa University Graduate School of Natural Science and Technology, 13-1 Takara-machi, Kanazawa, 920-0934 Ishikawa, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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