Linked Life Data

1449969

Source:http://linkedlifedata.com/resource/pubmed/id/1449969

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-1-7
pubmed:abstractText
This review discusses the relationship between tumour oxygenation status, tumour cell death and the 31P MRS parameters associated with cellular energy metabolism (phosphocreatine, nucleoside triphosphates and Pi). The presence of cells dying by apoptosis, and during mitosis would be unlikely to affect the 31P spectrum directly since they represent only a small fraction of tumour cells and remain energized until phagocytosed. Histologically necrotic cells also probably contribute nothing to the 31P spectrum. Instead, the spectrum appears to reflect the degree of hypoxia of the remaining viable cells, and the metabolic alterations required to sustain ATP synthesis as the oxygen supply diminishes. The biochemical theory developed to account for the 31P spectra of acutely hypoxic tissues does not apply to chronically hypoxic tumours. The concentrations of free ADP and Pi have major roles in the control of oxidative phosphorylation and glycolysis, as in normal tissues, but the precise relationships are still obscure. Cell-killing following therapy may indirectly affect 31P MRS parameters via changes in oxygen concentration brought about by an improvement in tumour blood flow and alterations in oxygen consumption rates and diffusion distances.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0952-3480
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
279-89
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
The contribution made by cell death and oxygenation to 31P MRS observations of tumour energy metabolism.
pubmed:affiliation
CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't