Linked Life Data

14499495

Source:http://linkedlifedata.com/resource/pubmed/id/14499495

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8-9
pubmed:dateCreated
2003-9-22
pubmed:abstractText
Prostaglandins (PGs) induced by UV may play important roles in UV-induced inflammation, photocarcinogenesis, and photoaging processes in human skin. The age-related PGE2 production and cyclooxygenase-2 (COX-2) expression in the human skin in vivo remain unclear. The purpose of this study was to examine the influence of aging on UV-induced PGE2 production and COX-2 expression in human skin in vivo. We found that aged human skin produces higher amounts of PGE2 than young skin, when exposed to UV. The inductions of COX-2 mRNA and protein by UV in aged skin were higher than those in the young skin, whereas COX-1 mRNA expression remained unchanged. Aged human macrophage expressed higher amounts of PGE2 and COX-2 protein constitutively, and also induced these species after LPS treatment more so than young cells. Our data suggest that skin aging may increase susceptibility to the development of skin cancer and photoaging, by enhanced PGE2 and COX-2 expression due to UV in human skin in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0047-6374
pubmed:author
pubmed:issnType
Print
pubmed:volume
124
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
903-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Enhanced expression of cylooxygenase-2 by UV in aged human skin in vivo.
pubmed:affiliation
Laboratory of Cutaneous Aging Research, Department of Dermatology, Clinical Research Institute, Seoul National University College of Medicine, Seoul National University Hospital, 28 Yongon-dong, Chongno-Gu, Seoul 110-744, South Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't