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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2003-9-22
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pubmed:abstractText |
The contribution of kinins to the beneficial effects of angiotensin I converting enzyme (ACE) inhibition in cardiovascular risk reduction remains unclear. The genes for the kinin inducible B1 receptor (B(1)R) and constitutive B2 receptor (B(2)R) contain functional variants: the B(1)R-699C (rather than G) and the B(2)R(-9) (rather than +9) alleles are associated with greater mRNA expression and the B(2)R(-9) allele with reduced left ventricular hypertrophic responses. We tested whether these gene variants influenced hypertensive coronary risk in a large prospective study.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0195-668X
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pubmed:author |
pubmed-author:CooperJacqueline AJA,
pubmed-author:DhamraitSukhbir SSS,
pubmed-author:HaweEmmaE,
pubmed-author:HumphriesSteve ESE,
pubmed-author:JonesAlunA,
pubmed-author:LiPingP,
pubmed-author:MillerGeorge JGJ,
pubmed-author:MontgomeryHugh EHE,
pubmed-author:PalmenJutta MJM,
pubmed-author:PayneJohn RJR,
pubmed-author:ToorIqbal SIS,
pubmed-author:WoottonPeter T EPT
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1672-80
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14499231-Blood Pressure,
pubmed-meshheading:14499231-Coronary Disease,
pubmed-meshheading:14499231-Disease-Free Survival,
pubmed-meshheading:14499231-Genotype,
pubmed-meshheading:14499231-Humans,
pubmed-meshheading:14499231-Hypertension,
pubmed-meshheading:14499231-Male,
pubmed-meshheading:14499231-Middle Aged,
pubmed-meshheading:14499231-Polymorphism, Genetic,
pubmed-meshheading:14499231-Prospective Studies,
pubmed-meshheading:14499231-Receptor, Bradykinin B1,
pubmed-meshheading:14499231-Receptor, Bradykinin B2,
pubmed-meshheading:14499231-Risk Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension.
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pubmed:affiliation |
Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free & University College London Medical School, Rayne Building, London, UK.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Multicenter Study
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