Linked Life Data

14499010

Source:http://linkedlifedata.com/resource/pubmed/id/14499010

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-9-22
pubmed:abstractText
This article attempts to provide the reader with a complete overview of topoisomerase (topo) II alpha as a marker for predicting the efficacy of anthracyclines in patients with breast cancer. In the first section of this article, in vitro data supporting the predictive value of topo II alpha are reviewed. Interestingly, these data suggest that the interaction between HER2 and anthracycline efficacy, which has been hypothesized in several clinical studies performed in the past decade, might depend on the concomitant topo II alpha status. Molecular pathology studies further reinforce the concept that HER2 might not be directly involved in the prediction of response to anthracyclines. They report that topo II alpha gene amplification can be found in 25%-40% of HER2/neu-amplified tumors, while no topo II gene amplification is detected in the absence of HER2/neu gene amplification. In the second part of this article, a series of clinical studies are reviewed and interpreted. These studies have attempted to correlate topo II alpha status with anthracycline efficacy in the adjuvant, neoadjuvant, and metastatic settings. All of the studies evaluating the topo II alpha gene suggest that gene amplification might be associated with an increased efficacy of anthracyclines, and some of the studies evaluating topo II alpha protein find that protein overexpression might correlate with an increased sensitivity to these compounds. Despite these findings, however, the reported studies do not provide the proof of principle needed to authorize the use of topo II alpha as a predictive marker for standard practice. A new generation of research is currently testing the predictive value of topo II alpha. It is hoped that these projects, which are described in the last section of the article, will clarify the role of topo IIa in the prediction of response to anthracyclines.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1526-8209
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-86
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Topoisomerase II alpha as a marker predicting the efficacy of anthracyclines in breast cancer: are we at the end of the beginning?
pubmed:affiliation
Department of Medical Oncology, Jules Bordet Institute, Brussels, Belgium. angelo.dileo@bordet.be
pubmed:publicationType
Journal Article, Review