Linked Life Data

1449231

Source:http://linkedlifedata.com/resource/pubmed/id/1449231

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1992-12-28
pubmed:abstractText
Polarographic current transients following a voltage step (turn-on transient) were measured with bare cathodes (25 microns diameter) and shallowly recessed oxygen microelectrodes (< 5 microns diameter). Except for the initial part of the current transient, the experimental measurements were in excellent agreement with simple models in the literature, which predict an inverse relationship with square root of t. Turn-on transients were measured in aqueous solutions with known physical properties, and in aortic wall tissue from three different species (n = 6 rabbits, n = 3 dogs, and n = 1 miniature pig). Oxygen diffusion coefficients (D) were determined in vitro by comparing time constants measured by the same microelectrode in saline and in strips of aortic wall tissue at 37 degrees C. On the inner side (endothelium and intima) of the aorta, D averaged (+/- S.E.) 7.0 (+/- 0.8) x 10(-6) cm2/s in 6 rabbits, 6.4 (+/- 1.0) x 10(-6) cm2/s in 3 dogs, and was 4.6 x 10(-6) cm2/s in the pig. On the adventitial side, D was 9.5 x 10(-6) cm2/s in 1 rabbit, 11.4 (+/- 1.2) x 10(-6) cm2/s in 3 dogs, and 8.1 x 10(-6) cm2/s in the pig. For every aortic strip on which D was measured from both sides, D for the inner wall was always lower, overall by a little more than one third (p < 0.001). The lower D on the endothelial side may limit oxygen transport to the vascular wall and play a role in atherogenesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0090-6964
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
629-46
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Spatial variation of aortic wall oxygen diffusion coefficient from transient polarographic measurements.
pubmed:affiliation
Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia 19104-6068.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't