Linked Life Data

1448545

Source:http://linkedlifedata.com/resource/pubmed/id/1448545

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
302
pubmed:dateCreated
1992-12-24
pubmed:abstractText
In a prospective study of 175 adult Asian patients attending a medical out-patient clinic we found a spectrum of metabolic bone disease. Twenty-four patients (13.5 per cent) had definite osteomalacia, of whom 11 (6 per cent) had severe clinical osteomalacia on the basis of associated symptoms and radiological signs. Fifteen (8.5 per cent) had borderline osteomalacia, while the remaining 136 (78 per cent) had normal bone biopsy, or were presumed to be normal. This histological spectrum was paralleled by the increasing prevalence of musculoskeletal symptoms (thigh pain, change in gait and difficulty rising from seated position) attributable to osteomalacia. Multivariate analysis showed that the major determinant of osteomalacia in Asians in South London was vegetarian diet. Increasing severity of bone disease was associated with increasingly strict vegetarian practice, which accounted for the excess risk of females, Hindus, and Asians originating from East Africa. Covering skin when outdoors also contributed to the female excess risk, and suggested a role for reduced solar exposure. Clinically significant osteomalacia is underdiagnosed in the Asian population, but evidence of dietary adaptation suggests this problem may diminish with time.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0033-5622
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
439-48
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Clinical and histological spectrum of osteomalacia among Asians in south London.
pubmed:affiliation
St George's Hospital and Medical School, London.
pubmed:publicationType
Journal Article