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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1992-12-29
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pubmed:abstractText |
Nerve regeneration across peripheral nerve allografts and control autografts in primates immunosuppressed with Cyclosporin A was quantitatively evaluated by electrophysiologic and histologic methods. Twelve cynomolgus monkeys received 3-cm autografts and allografts in contralateral ulnar nerves. They were immunosuppressed with Cyclosporin A at 25 mg/kg per day or placebo vehicle. Morphometric analysis of nerve graft and distal nerve segments was assessed at 1 year after engraftment. Quantitative electrophysiologic studies were performed percutaneously at 6 and 12 months, and compound action potentials were measured directly across the nerve grafts at 1 year. Excellent regeneration was seen across autografts and allografts in Cyclosporin A-treated and placebo-treated recipients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0032-1052
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1036-46
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pubmed:dateRevised |
2011-2-16
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pubmed:meshHeading |
pubmed-meshheading:1448498-Action Potentials,
pubmed-meshheading:1448498-Animals,
pubmed-meshheading:1448498-Cyclosporine,
pubmed-meshheading:1448498-Electromyography,
pubmed-meshheading:1448498-Graft Rejection,
pubmed-meshheading:1448498-Histocompatibility Antigens Class I,
pubmed-meshheading:1448498-Immunocompromised Host,
pubmed-meshheading:1448498-Lymphocytes,
pubmed-meshheading:1448498-Macaca fascicularis,
pubmed-meshheading:1448498-Male,
pubmed-meshheading:1448498-Motor Neurons,
pubmed-meshheading:1448498-Nerve Fibers,
pubmed-meshheading:1448498-Nerve Regeneration,
pubmed-meshheading:1448498-Neural Conduction,
pubmed-meshheading:1448498-Placebos,
pubmed-meshheading:1448498-Prospective Studies,
pubmed-meshheading:1448498-Random Allocation,
pubmed-meshheading:1448498-Sural Nerve,
pubmed-meshheading:1448498-Transplantation, Autologous,
pubmed-meshheading:1448498-Transplantation, Homologous,
pubmed-meshheading:1448498-Ulnar Nerve
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pubmed:year |
1992
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pubmed:articleTitle |
The peripheral nerve allograft in the primate immunosuppressed with Cyclosporin A: I. Histologic and electrophysiologic assessment.
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pubmed:affiliation |
Department of Surgery, University of Toronto, Ont., Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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