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rdf:type |
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lifeskim:mentions |
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0205263,
umls-concept:C1261381,
umls-concept:C1332714,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1522642,
umls-concept:C1611645,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
12
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pubmed:dateCreated |
1992-12-28
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pubmed:abstractText |
A panel of CD4+ T-cell clones has been isolated from the spleen and lymph nodes of diabetic NOD mice. These clones have been shown to be islet-specific both in vivo and in vitro. One of the clones, BDC-6.9, initiates extensive damage to islet tissue when placed adjacent to an NOD islet graft that has been used to reverse diabetes in (CBA x NOD)F1 recipients or when injected intraperitoneally into such animals. In this study, we show that BDC-6.9 T cells can initiate islet destruction in the absence of detectable CD8 T cells either in the periphery or in the lesion that develops after the transfer of the cloned islet-reactive T cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0012-1797
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1603-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1446802-Animals,
pubmed-meshheading:1446802-Antibodies, Monoclonal,
pubmed-meshheading:1446802-Antigens, CD4,
pubmed-meshheading:1446802-Antigens, CD8,
pubmed-meshheading:1446802-Blood Glucose,
pubmed-meshheading:1446802-Cells, Cultured,
pubmed-meshheading:1446802-Crosses, Genetic,
pubmed-meshheading:1446802-Diabetes Mellitus, Type 1,
pubmed-meshheading:1446802-Female,
pubmed-meshheading:1446802-Flow Cytometry,
pubmed-meshheading:1446802-Islets of Langerhans,
pubmed-meshheading:1446802-Islets of Langerhans Transplantation,
pubmed-meshheading:1446802-Kidney Transplantation,
pubmed-meshheading:1446802-Lymph Nodes,
pubmed-meshheading:1446802-Lymphocyte Depletion,
pubmed-meshheading:1446802-Male,
pubmed-meshheading:1446802-Mice,
pubmed-meshheading:1446802-Mice, Inbred NOD,
pubmed-meshheading:1446802-Mice, Inbred Strains,
pubmed-meshheading:1446802-Spleen,
pubmed-meshheading:1446802-T-Lymphocyte Subsets
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pubmed:year |
1992
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pubmed:articleTitle |
CD8 T cells are not required for islet destruction induced by a CD4+ islet-specific T-cell clone.
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pubmed:affiliation |
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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