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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1992-12-22
|
| pubmed:abstractText |
Deletion mutagenesis in human NAD(P)H:Quinone Oxidoreductase (NQO1) gene and transfection studies into mammalian cells identified a segment of DNA designated as human Antioxidant Response Element (hARE) responsible for high basal expression in tumor cells and its induction by beta-naphthoflavone (beta-NF). The twenty four base pairs of the hARE contains an essential cis-element AP1 binding site and has been shown to bind to jun-D and c-fos proteins from mouse hepatoma (Hepa-1) nuclear extract. In the present report, we have identified jun-B as the third major protein in the hARE-Hepa-1 proteins complex observed in the band shift assays.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0006-291X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
16
|
| pubmed:volume |
188
|
| pubmed:geneSymbol |
jun-B
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
992-6
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1445367-Base Sequence,
pubmed-meshheading:1445367-Cell Nucleus,
pubmed-meshheading:1445367-Humans,
pubmed-meshheading:1445367-Molecular Sequence Data,
pubmed-meshheading:1445367-NAD(P)H Dehydrogenase (Quinone),
pubmed-meshheading:1445367-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:1445367-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:1445367-Transcription, Genetic
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Identification of jun-B as third member in human antioxidant response element-nuclear proteins complex.
|
| pubmed:affiliation |
Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, PA 19111.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|