Linked Life Data

14449551

Source:http://linkedlifedata.com/resource/pubmed/id/14449551

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1962-12-1
pubmed:abstractText
A general method of determining the nature of the genotypes in mutants of transformable bacteria with similar phenotypes is discussed. The method is used to identify the genotypic patterns of three mutants of Hemophilus influenzae which are resistant to different levels of streptomycin. A mutant resistant to 700 microg per ml of the antibiotic was found to be made up of two unlinked, independent loci-presumably on different molecules of transforming DNA. These loci, when in separate cells, render them resistant to maximum levels of 10 and 100 microg per ml streptomycin respectively and are therefore designated as Sm(10) and Sm(100). When they enter the same cell they produce a resistance up to 700 microg per ml streptomycin, so the cells are noted as Sm(700). This multiplicative action is more easily visualized as due to two independent processes of combating the antibiotic which enhance each other rather than two identical processes.
pubmed:commentsCorrections
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
OM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1295
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
197-204
pubmed:dateRevised
2010-6-22
pubmed:meshHeading
pubmed:year
1961
pubmed:articleTitle
Studies on transformations of Hemophilus influenzae. III. The genotypes and phenotypic patterns of three streptomycin-resistant mutants.
pubmed:publicationType
Journal Article