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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1992-12-8
|
| pubmed:abstractText |
From 1980 to 1991, 29 patients underwent complex reconstruction following extremity sarcoma resection. Soft tissue was the site of origin in 15 patients (52%) and bone was the site of origin in 14 patients (48%), with 20 sarcomas (69%) in the lower extremity. Resection consisted of the following procedures: extended anatomical soft-tissue resections (21 patients [72%]), bone resections (18 patients [62%]), and joint resections (14 patients [48%]). Reconstruction involved the following: myocutaneous flaps (20 patients [69%]), joint prosthesis (eight patients [28%]), and bone reconstruction (15 patients [52%]). There was no surgical mortality; one patient required an amputation owing to surgical complications. The site of the first failure was local (four [31%] of 13 patients), lung (five patients [38%]), others (four patients [31%]). At a median follow-up of 23 months, 18 patients (62%) had no evidence of disease, 27 (93%) had no local disease, 21 (72%) had good extremity function, three (10%) had major disabilities, and five (17%) underwent amputations. Local control improved when the margin of resection was larger than 10 mm. Disease-free survival was 67% at 3 years. Overall survival was 51% at 5 years. Tumor size was an independent predictor of overall survival. Local recurrence did not affect overall survival.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0004-0010
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
127
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1278-81
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1444786-Adult,
pubmed-meshheading:1444786-Aged,
pubmed-meshheading:1444786-Bone Neoplasms,
pubmed-meshheading:1444786-Bone Transplantation,
pubmed-meshheading:1444786-California,
pubmed-meshheading:1444786-Chemotherapy, Adjuvant,
pubmed-meshheading:1444786-Combined Modality Therapy,
pubmed-meshheading:1444786-Extremities,
pubmed-meshheading:1444786-Female,
pubmed-meshheading:1444786-Follow-Up Studies,
pubmed-meshheading:1444786-Humans,
pubmed-meshheading:1444786-Joint Prosthesis,
pubmed-meshheading:1444786-Male,
pubmed-meshheading:1444786-Middle Aged,
pubmed-meshheading:1444786-Neoplasm Recurrence, Local,
pubmed-meshheading:1444786-Orthopedics,
pubmed-meshheading:1444786-Postoperative Complications,
pubmed-meshheading:1444786-Prognosis,
pubmed-meshheading:1444786-Radiotherapy,
pubmed-meshheading:1444786-Sarcoma,
pubmed-meshheading:1444786-Soft Tissue Neoplasms,
pubmed-meshheading:1444786-Surgery, Plastic,
pubmed-meshheading:1444786-Surgical Flaps,
pubmed-meshheading:1444786-Survival Rate,
pubmed-meshheading:1444786-Treatment Outcome
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Extended indications for functional limb-sparing surgery in extremity sarcoma using complex reconstruction.
|
| pubmed:affiliation |
Department of General Oncologic Surgery, City of Hope National Medical Center, Duarte, Calif. 91010.
|
| pubmed:publicationType |
Journal Article
|