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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1992-12-18
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pubmed:abstractText |
Low-dose trimethoprim-sulfamethoxazole (TMP-SMX) alone was found to be as effective as low-dose TMP-SMX plus zidovudine and standard-dose TMP-SMX alone in preventing and treating Pneumocystis carinii pneumonia (PCP) in an immunosuppressed-rat model. Zidovudine alone had no preventive or curative effect on PCP. We conclude that the initially reported reduced incidence of PCP in human immunodeficiency virus-infected patients treated with zidovudine alone is not due to anti-P. carinii activity of zidovudine. Furthermore, the clinical efficacy of low-dose TMP-SMX for the prevention and treatment of PCP should be further investigated.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-1671479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-1799277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-1901482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-1952835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-1977079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-1988528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-2016690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-221230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-2658792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-315677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-3257532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-3260765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-3261959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-3299089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-3495732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-3499116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-4365115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-5297332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1444313-6335017
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2328-30
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1444313-Animals,
pubmed-meshheading:1444313-Body Weight,
pubmed-meshheading:1444313-Drug Evaluation, Preclinical,
pubmed-meshheading:1444313-Drug Therapy, Combination,
pubmed-meshheading:1444313-Immunosuppression,
pubmed-meshheading:1444313-Male,
pubmed-meshheading:1444313-Mice,
pubmed-meshheading:1444313-Pneumonia, Pneumocystis,
pubmed-meshheading:1444313-Rats,
pubmed-meshheading:1444313-Rats, Wistar,
pubmed-meshheading:1444313-Trimethoprim-Sulfamethoxazole Combination,
pubmed-meshheading:1444313-Zidovudine
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pubmed:year |
1992
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pubmed:articleTitle |
Low-dose trimethoprim-sulfamethoxazole alone and in association with zidovudine for prevention and treatment of murine Pneumocystis carinii pneumonia.
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pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale, U. 13, Hôpital Claude Bernard, Paris, France.
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pubmed:publicationType |
Journal Article
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