Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4A Suppl
|
| pubmed:dateCreated |
1992-12-18
|
| pubmed:abstractText |
Two dose schedules of the antibiotic cefotaxime were compared in a prospective, randomized 226-center study of 3,670 patients undergoing abdominal, gynecologic, and urologic surgery. Schedule A consisted of a single preoperative dose and schedule B consisted of one preoperative dose followed by two postoperative doses. There was no significant difference in the frequency of wound infection or bacteriuria between the two schedules. Schedule B was associated with a significantly higher incidence of postoperative pyrexia, further antibiotic therapy, local side effects, and extended hospital stay. One dose probably has less impact on the intestinal flora. Therefore, single-dose cefotaxime is as effective and less costly when compared with multiple-dose cefotaxime for common surgical procedures lasting less than 3 hours.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0002-9610
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
164
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
16S-20S
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1443354-Abdomen,
pubmed-meshheading:1443354-Adolescent,
pubmed-meshheading:1443354-Adult,
pubmed-meshheading:1443354-Aged,
pubmed-meshheading:1443354-Aged, 80 and over,
pubmed-meshheading:1443354-Bacterial Infections,
pubmed-meshheading:1443354-Cefotaxime,
pubmed-meshheading:1443354-Child,
pubmed-meshheading:1443354-Child, Preschool,
pubmed-meshheading:1443354-Drug Administration Schedule,
pubmed-meshheading:1443354-Female,
pubmed-meshheading:1443354-Fever,
pubmed-meshheading:1443354-Humans,
pubmed-meshheading:1443354-Hysterectomy,
pubmed-meshheading:1443354-Length of Stay,
pubmed-meshheading:1443354-Middle Aged,
pubmed-meshheading:1443354-Postoperative Complications,
pubmed-meshheading:1443354-Premedication,
pubmed-meshheading:1443354-Prospective Studies,
pubmed-meshheading:1443354-Surgical Wound Infection,
pubmed-meshheading:1443354-Urinary Tract
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
New clinical data on the prophylaxis of infections in abdominal, gynecologic, and urologic surgery. Multicenter Study Group.
|
| pubmed:affiliation |
Istituto di Microbiologia, Università degli Studi di Brescia, Italy.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|