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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1992-12-9
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pubmed:abstractText |
Fulvotomentosides (Ful) is the total saponins of Lonicera fulvotomentosa. In the present study, we examined the effect of Ful on acetaminophen (AA)-induced hepatotoxicity in mice. Ful pretreatment (75-225 mg.kg-1, sc x 3 d) significantly decreased AA (500 mg.kg-1, ip)-induced liver damage as indicated by serum activities of alanine aminotransferase and sorbitol dehydrogenase. Ful pretreatment (225 mg.kg-1, sc x 3 d) decreased hepatic cytochrome P-450, cytochrome b5, and NADPH-cytochrome c reductase by approximately 15-20%. Microsomes from Ful-pretreated mice, incubated in vitro with AA, produced less AA-glutathione. A 28% increase in urinary excretion of AA-glucuronide was observed in Ful (150 mg.kg-1, sc x 3 d) pretreated mice. Ful pretreatment had no influence on liver UDP-glucuronic acid concentration, but increased hepatic glucuronyltransferase activity towards AA. In summary, Ful pretreatment protects against AA-induced hepatotoxicity. One of the mechanisms for this protection appears to be the decreased AA toxic activation via P-450, as well as increased detoxication via glucuronidation of AA.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetaminophen,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronosyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Oleanolic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Saponins,
http://linkedlifedata.com/resource/pubmed/chemical/acetaminophen glucuronide,
http://linkedlifedata.com/resource/pubmed/chemical/fulvotomentoside A
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0253-9756
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
209-12
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1442100-Acetaminophen,
pubmed-meshheading:1442100-Animals,
pubmed-meshheading:1442100-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:1442100-Cytochrome P-450 Enzyme System,
pubmed-meshheading:1442100-Drug-Induced Liver Injury,
pubmed-meshheading:1442100-Glucuronosyltransferase,
pubmed-meshheading:1442100-Male,
pubmed-meshheading:1442100-Metabolic Detoxication, Drug,
pubmed-meshheading:1442100-Mice,
pubmed-meshheading:1442100-Microsomes, Liver,
pubmed-meshheading:1442100-Oleanolic Acid,
pubmed-meshheading:1442100-Saponins
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pubmed:year |
1992
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pubmed:articleTitle |
Protective effects of fulvotomentosides on acetaminophen-induced hepatotoxicity.
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pubmed:affiliation |
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160-7417.
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pubmed:publicationType |
Journal Article
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